2017 Fiscal Year Final Research Report
Mechanisms underlying drug-induced tubulointerstitial nephritis
| Project/Area Number |
16K18939
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
|
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 尿細管間質性腎炎 / 抗菌薬 / NSAIDs / 腸内細菌叢 |
|---|
| Outline of Final Research Achievements |
Drug-induced renal tubulointerstitial nephritis is characterized by inflammation in renal interstitium, which can cause chronic renal dysfunction and anemia. However, the mechanisms underlying pathogenesis of tubulointerstitial nephritis remained unclear. In this study, we aimed to elucidate the mechanism of drug-induced tubulointerstitial nephritis based on the concept that factors outside the kidneys are involved in the development of tubulointerstitial nephritis. Analysis focusing on antimicrobial drugs and intestinal bacterial flora demonstrated that the intestinal flora is involved in the development of drug-induced tubulointerstitial nephritis.
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| Free Research Field |
医療薬学
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