Mechanisms underlying drug-induced tubulointerstitial nephritis
Project/Area Number |
16K18939
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 尿細管間質性腎炎 / 抗菌薬 / NSAIDs / 腸内細菌叢 / 腸内細菌 / 薬剤性腎障害 |
Outline of Final Research Achievements |
Drug-induced renal tubulointerstitial nephritis is characterized by inflammation in renal interstitium, which can cause chronic renal dysfunction and anemia. However, the mechanisms underlying pathogenesis of tubulointerstitial nephritis remained unclear. In this study, we aimed to elucidate the mechanism of drug-induced tubulointerstitial nephritis based on the concept that factors outside the kidneys are involved in the development of tubulointerstitial nephritis. Analysis focusing on antimicrobial drugs and intestinal bacterial flora demonstrated that the intestinal flora is involved in the development of drug-induced tubulointerstitial nephritis.
|
Report
(3 results)
Research Products
(8 results)
-
-
-
-
-
[Journal Article] Disruption of Slc52a3 gene causes neonatal lethality with riboflavin deficiency in mice2016
Author(s)
Yoshimatsu H, Yonezawa A, Yamanishi K, Yao Y, Sugano K, Nakagawa S, Imai S, Omura T, Nakagawa T, Yano I, Masuda S, Inui K & Matsubara K
-
Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 27557-27557
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Presentation] Long-term renal outcomes of cisplatin-induced nephropathy2018
Author(s)
Mayuko Kurimura, Shunsaku Nakagawa, Shota Takao, Yuki Okuda, Misako Nakamura, Yuki Otani, Tomohiro Omura, Satoshi Imai, Atsushi Yonezawa, Takayuki Nakagawa, Kazuo Matsubara
Organizer
ISN Frontiers Meetings
Related Report
Int'l Joint Research
-
-