| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The animal experiments using ob/ob mice showed that the distribution of adipocytes was shifted to a smaller cell size and insulin sensitivity was improved by entinostat. These changes were considered to be due to the increased expression of
Ppar-γ (regulator of adipocyte differentiation) mediated by the increase of DBP protein.
In a study using human visceral adipose tissue, mRNA expressions of Dbp and Ppar-γ were also significantly lower in type 2 diabetic patients than in non-diabetic patients. These observations were similar to those in animal experiments. Such a difference between type 2 diabetic patients and non-diabetic patients was observed in omental adipose tissue, but not in mesenteric adipose tissue.
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