| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Disseminated intravascular coagulation (DIC) is seen in patients with systemic inflammation. In this study, we used DIC model animal induced by extracellular histones to screen new therapeutic agents. We focused on the cross-talk between complement and coagulation system, and investigated whether an anti-complement drug ameliorated DIC. Complement component 5a (C5a) receptor antagonist ameliorated liver injury in DIC. Heparin and chondroitin sulfate (CS) are linear polysaccharides, and its negative charge allows binding to extracellular histones. Our study elucidated that the interaction between CS and extracellular histones did not affect coagulation system in DIC.
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