| Project/Area Number |
16K18973
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Kiyoshi Masato 国立医薬品食品衛生研究所, 生物薬品部, 研究員 (60754314)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | FcRL / IgG / リガンド / 安定性 / リガンド探索 / SPR / 親和性 / 分子間相互作用 / Fc Receptor-Like Protein / 抗体医薬品 / 免疫応答 / 分子認識 / 機能解析 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the relationship between the biological response mediated by Fc receptor-like protein (FcRL) and the efficacy / safety of antibody drugs, and to utilize it for molecular design and quality evaluation and management of antibody drugs. Moreover, this study focuses on the molecular recognition mechanism of FcRL to its ligands and perform functional analysis. We analyzed the binding properties of antibody subtype to five subtypes FcRL1, FcRL2, FcRL3, FcRL5 and FcRLB using Surface Plasmon Resonance (SPR) method.
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