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Analysis for GluD1-Cbln1 signaling in synaptic transmission in thalamic neurons of the ventral posteromedial nucleus

Research Project

Project/Area Number 16K18974
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionHokkaido University

Principal Investigator

Konno Kotaro  北海道大学, 医学研究院, 助教 (20599641)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsgulutamate receptor / グルタミン酸受容体 / 機能解剖学
Outline of Final Research Achievements

We selected the ventral posterior nucleus (VP), a brain region with high level expression of GluD1. GluD1 mRNA was expressed highly in relay neurons, and its immunoreactivity was selectively concentrated at specific synapses formed between glutamatergic neurons in the trigeminal nucleus and relay neurons in the VP. In addition, most VP-targeting neurons expressed Cbln1 mRNA, a ligand for GluD1. To pursue a role of the interaction of GluD1 and Cbln1 in the VP, we analyzed changes in terminals of trigeminal nucleus in wild-type, GluD1-KO, and Cbln1-KO mice by immunofluorescence. In GluD1-knockout and Cbln1-knockout mice, the density of glutamatergic terminals were strikingly increased. These results suggest that GluD1 and Cbln1 interaction plays a inhibitory role in synaptic connectivity between glutamatergic neurons in the trigeminal nucleus and relay neurons in the VP.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Repeated fluvoxamine treatment recovers early postnatal stress-induced hypersociability-like behavior in adult rats.2018

    • Author(s)
      Kumamoto H, Yamaguchi T, Konno K, Izumi T, Yoshida T, Ohmura Y, Watanabe M, Yoshioka M
    • Journal Title

      Journal Pharmacological Science

      Volume: 136 Issue: 1 Pages: 1-8

    • DOI

      10.1016/j.jphs.2017.12.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.2018

    • Author(s)
      Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
    • Journal Title

      Neurochem Int

      Volume: S0197-0186 Issue: 17 Pages: 30442-4

    • DOI

      10.1016/j.neuint.2018.01.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum2018

    • Author(s)
      Uesaka Naofumi、Abe Manabu、Konno Kohtarou、Yamazaki Maya、Sakoori Kazuto、Watanabe Takaki、Kao Tzu-Huei、Mikuni Takayasu、Watanabe Masahiko、Sakimura Kenji、Kano Masanobu
    • Journal Title

      Neuron

      Volume: 97 Issue: 4 Pages: 796

    • DOI

      10.1016/j.neuron.2018.01.018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of Cbln1 in Non-Motor Functions of Mice2016

    • Author(s)
      Otsuka S, Konno K, Abe M, Motohashi J, Kohda K, Sakimura K, Watanabe M, Yuzaki M
    • Journal Title

      Journal of Neuroscience

      Volume: 36 Issue: 46 Pages: 11801-11816

    • DOI

      10.1523/jneurosci.0322-16.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Extracerebellar localization of glutamate receptor GluD22018

    • Author(s)
      Kohtarou Konno, Kenji Sakimura, Masahiko Watanabe
    • Organizer
      第8回新潟大学脳研究所共同研究拠点国際シンポジウム(新潟県新潟市)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス視床後腹側核におけるグルタミン酸受容体GluD1の局在および機能解析2017

    • Author(s)
      宮本哲愼、今野幸太郎、西川晃司、崎村建司、柚崎通介、渡辺雅彦
    • Organizer
      第122回日本解剖学会総会・全国集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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