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Role of ghrelin on environment-dependent wakefulness induction

Research Project

Project/Area Number 16K19004
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionUniversity of Toyama

Principal Investigator

Kim Juhyon  富山大学, 大学院理工学研究部(工学), 講師 (00635146)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsグレリン / 睡眠・覚醒
Outline of Final Research Achievements

Ghrelin, an endogenous peptide produced in stomach and brain, plays a crucial role in feeding behavior and growth hormone secretion. Some studies using rodents with administration of ghrelin or the receptor-KO also indicated that ghrelin regulates sleep-wakefulness, especially environment-dependent wakefulness (wake) induction. However, the mechanism has not been fully elucidated. Present study using rats demonstrated that ghrelin facilitates neuronal activity of tuberomammillary nucleus, one of wake-promoting nuclei, and affects sleep-wake pattern.

Academic Significance and Societal Importance of the Research Achievements

環境変化に対する適応反応や注意、認知反応には適切な覚醒レベルの維持が必須であり、上記の先行報告は覚醒反応におけるグレリンシグナリングの重要性を示唆する。本研究成果は睡眠・覚醒制御機構における知見に重要な基礎を与えるものである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2019 2018 2017

All Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Ghrelin modulates duration or number of wakefulness, NREM and REM sleep event2019

    • Author(s)
      Okumura R, Tajima T, Mukai T, Yamashita D, Kakizawa T, Kim J, Nakajima K
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グレリンによる睡眠・覚醒への影響と活性化脳領域の検証2018

    • Author(s)
      奥村亮典,但馬俊貴,向 拓也,山下大海,柿澤太一,金 主賢,中島一樹
    • Organizer
      日本生体医工学会北陸支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of ghrelin on the locus coeruleus neurons in rats2017

    • Author(s)
      Juhyon Kim, Daisuke Shima, Yuto Ikai, Toshiki Tajima, Kazuki Nakajima
    • Organizer
      The 2017 annual meeting of Society for Neuroscience (Neuroscience 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2023-12-25  

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