Beneficial role of plasmalogens in the brain which are reduced by ageing, stress and neuroinflammation

• Project/Area Number: 16K19007
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kyushu University
• Principal Investigator: Hossain Shamim 九州大学, 医学研究院, 准教授 (40647707)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: Plasmalogens / glial activation / neurotrophic factor / memory / Hippocampus / plasmalogens / hippocampus / spatial learning / orphan GPR / NF-kB / c-Myc / シグナル伝達 / アルツハイマー病 / プラズマローゲン / 神経炎症 / 学習記憶

Outline of Final Research Achievements

In my two-years study, I observed that Plasmalogens (Pls) improved hippocampal dependent memory in mice by activating the BDNF and TrkB signaling (paper under revision). Oral ingestion of Pls attenuated the lipopolysaccharide-induced glial activation and amyloid beta (Aβ) deposition in the mice resulting in the cognition improvement (Hossain MS et al., BBRC, 2018). I also clarified of how these lipids are reduced in the brain by aging, stress and inflammation via the NF-kB and c-Myc pathways (Hossain MS et al., J Neurosci., 2017). A possible functional interaction of Pls with some nuclear receptors and orphan G-protein coupled receptor (GPCR) proteins was also observed, which might help us to understand the diverse role of Pls in our health. In addition, I also observe the epigenetic regulation of neurotrophic factors in the murine brain to better understand the memory process (Hossain et al., Mol. Neurobio., 2017).

Research Products

• [Journal Article] Oral ingestion of plasmalogens can attenuate the LPS-induced memory loss and microglial activation. (2018)
  • Author(s): Hossain MS, Tajima A, Kotoura S, Katafuchi T
  • Journal Title: Biochem Biophys Res Commun Volume: 496(4) Issue: 4 Pages: 1033-1039
  • DOI: 10.1016/j.bbrc.2018.01.078
  • Peer Reviewed / Open Access
• [Journal Article] Glucose can epigenetically alter the gene expression of neurotrophic factors in the murine brain cells. (2017)
  • Author(s): Hossain MS,Oomura Y,and Katafuchi T
  • Journal Title: Molecular Neurobiology Volume: 55(4) Issue: 4 Pages: 3408-3425
  • DOI: 10.1007/s12035-017-0578-3
  • Peer Reviewed / Open Access
• [Journal Article] Glucose can epigenetically alter the gene expression of neurotrophic factors in the murine brain cells. (2017)
  • Author(s): Hossain MS, Oomura Y, Katafuchi, T.
  • Journal Title: Molecular Neurobiology Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reduction of ether-type glycerophospholipids, plasmalogens, by NF-κB signal leading to microglial activation (2017)
  • Author(s): Hossain, Md. S., Abe, Y., Ali, F., Youssef, M., Honsho, M., Fujiki, Y., and *Katafuchi, T.
  • Journal Title: J. Neurosci. Volume: 37 Issue: 15 Pages: 4074-4092
  • DOI: 10.1523/jneurosci.3941-15.2017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuronal orphan G-protein coupled receptor proteins mediate plasmalogens-induced activation of ERK and １Akt signaling. (2016)
  • Author(s): Hossain MS, Mineno K, Katafuchi T
  • Journal Title: PLoS ONE Volume: 11 Issue: 3 Pages: e0150846-e0150846
  • DOI: 10.1371/journal.pone.0150846
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Roles of brain lipids in glial activation. (2016)
  • Author(s): Hossain MS, Katafuchi T.
  • Journal Title: Advances in Neuroimmune Biology Volume: 6(2) Pages: 61-67
  • Peer Reviewed / Open Access
• [Journal Article] Functional involvement of brain lipids in the neuronal survival and anti-neuroinflammation. (2016)
  • Author(s): Hossain MS, Katafuchi T
  • Journal Title: Journal of Fatigue Science Volume: 11 (2) Pages: 7-17
  • Peer Reviewed
• [Presentation] Plasmalogens synthesis in the brain is down regulated during neuroinflammation. (2017)
  • Author(s): Hossain MS, Ali F, Katafuchi T.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（浜松）
  • Year and Date: 2017-03-28
• [Presentation] Glucose-induced cell specific expression of BDNF and FGF-1 in the mouse hippocampus:an involvement of epigenetic modifications (2017)
  • Author(s): Yutaka Oomura,Shamim M.Hossain,Toshihiko Katafuchi
  • Organizer: 第40回 日本神経科学大会
• [Presentation] Reduction of Ether-type Glycerophospholipids,Plasmalogens,in the Mouse Hippocampus induced by Inflammatory Signals,Aging and Chronic Stress (2017)
  • Author(s): Toshihiko Katafuchi,Shamim M.Hossain
  • Organizer: 第40回 日本神経科学大会
• [Presentation] Plasmalogens improve hippocampal dependent memory by activating BDNF-TrKB signaling in the hippocampus. (2016)
  • Author(s): Hossain MS, Katafuchi T.
  • Organizer: The 8th International Conference on Research in Science and Technology (ICRST).
  • Place of Presentation: Flora Grand Hotel (ドバイ United Arab Emirates (UAE)
  • Year and Date: 2016-12-20
  • Int'l Joint Research / Invited
• [Presentation] Reduction of Plasmalogens in the brain is associated with microglial activation, stress and aging. (2016)
  • Author(s): Hossain MS, Abe Y, Ali F, Youssef M, Honsho M, Fujiki Y, Katafuchi T.
  • Organizer: The 1st International Plasmalogen Symposium.
  • Place of Presentation: 九州大学百年講堂（福岡）
  • Year and Date: 2016-11-07
  • Int'l Joint Research
• [Presentation] The special lipids, plasmalogens, improve memory by accelerating BDNF-TrkB signaling in the hippocampus . (2016)
  • Author(s): Hossain MS, Ifuku M, Abe Y, Honsho M, Kawamura J, Miyake K, Fujiki Y, Katafuchi T.
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society.
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2016-07-20