| Project/Area Number |
16K19007
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Plasmalogens / glial activation / neurotrophic factor / memory / Hippocampus / plasmalogens / hippocampus / spatial learning / orphan GPR / NF-kB / c-Myc / シグナル伝達 / アルツハイマー病 / プラズマローゲン / 神経炎症 / 学習記憶 |
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| Outline of Final Research Achievements |
In my two-years study, I observed that Plasmalogens (Pls) improved hippocampal dependent memory in mice by activating the BDNF and TrkB signaling (paper under revision). Oral ingestion of Pls attenuated the lipopolysaccharide-induced glial activation and amyloid beta (Aβ) deposition in the mice resulting in the cognition improvement (Hossain MS et al., BBRC, 2018). I also clarified of how these lipids are reduced in the brain by aging, stress and inflammation via the NF-kB and c-Myc pathways (Hossain MS et al., J Neurosci., 2017). A possible functional interaction of Pls with some nuclear receptors and orphan G-protein coupled receptor (GPCR) proteins was also observed, which might help us to understand the diverse role of Pls in our health. In addition, I also observe the epigenetic regulation of neurotrophic factors in the murine brain to better understand the memory process (Hossain et al., Mol. Neurobio., 2017).
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