Dissecting the functional role of a novel ligand for APJ, ELABELA, in cardio-renal connection
| Project/Area Number |
16K19013
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Akita University |
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Principal Investigator |
SATO Teruki 秋田大学, 医学(系)研究科(研究院), 助教 (30733422)
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| Co-Investigator(Renkei-kenkyūsha) |
Kuba Keiji 秋田大学, 大学院医学系研究科 分子機能学・代謝機能学講座, 教授 (10451915)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ELABELA / APJ / 心不全 / 心腎連関 / 心保護効果 / レニンアンジオテンシン系 / 心肥大 |
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| Outline of Final Research Achievements |
In this study, we investigated the functional role of a novel ligand for APJ receptor, ELABELA, in controlling heart function. ELABELA has been identified as a second ligand for APJ receptor, while Apelin has been thought to be only ligand for APJ receptor. We showed that ELABELA-APJ axis protects from pressure overload-induced heart failure possibly via suppression of ACE expression. In addition, we analyzed the role of ELA in the renal collecting duct.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage2017
Author(s)
Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K
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Journal Title
Cardiovasc Res
Volume: 113(7)
Issue: 7
Pages: 760-769
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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