Identification of factors involved in the amino acid signaling to mTOR in lysosome and clarification of its functional significance
| Project/Area Number |
16K19018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
Okuda Suguru 大阪大学, 医学系研究科, 助教 (50511846)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アミノ酸 / トランスポーター / mTOR / 細胞増殖 / 情報伝達 / 機能解析 / 蛋白質 / シグナル伝達 |
|---|
| Outline of Final Research Achievements |
To understand the mechanism of cell growth and proliferation induced by amino acids, we sought factors involved in the process, and analyzed an amino acid transporter localizing cell membrane to take amino acids into cells. We successfully determined in which tissue one of the uncharacterized transporters exist, and identified candidates that interacts with the amino acid transporter and may affect its function.
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| Academic Significance and Societal Importance of the Research Achievements |
アミノ酸輸送体のなかにはその機能が病気に関連するものが多数存在する。例えば、がんにおいては一部のアミノ酸輸送体が正常な細胞より多く存在するため、アミノ酸の取り込みが速く、細胞の成長・増殖も早い。本研究の成果はアミノ酸による細胞成長・増殖の仕組みを解明するために重要な知見であり、将来的には本研究の成果が新たな薬の開発に繋がることが期待される。
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Report
(4 results)
Research Products
(24 results)
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[Presentation] PEPT1-targeted boron delivery for boron neutron capture therapy using BPA-containing dipeptide2019
Author(s)
Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Lili Quan, Chunhuan Jin, Xingming Liu, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
Organizer
第92回 日本薬理学会年会
Related Report
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[Presentation] BPA-dipeptides, novel boron delivery agents for boron neutron capture therapy, are transported by oligopeptide transporter2018
Author(s)
Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
Organizer
WCP2018 KYOTO 18th World congress of basic and clinical pharmacology
Related Report
Int'l Joint Research
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