| Project/Area Number |
16K19045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | コレクチン / 3MC症候群 / 発生 / 自然免疫 |
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| Outline of Final Research Achievements |
The association between the gene defect of collectin CL-K1 and the pathology of 3MC syndrome has been found, suggesting that CL-K1 may be involved in growth and development. The purpose of this study is to elucidate the pathogenesis of 3MC syndrome in order to explore the possibility of establishing a medical treatment for it. I found that CL-K1 interacts with collectin CL-L1, suggesting that CL-L1 may also be related to the pathogenesis of 3MC syndrome.
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| Academic Significance and Societal Importance of the Research Achievements |
3MC症候群の発症原因は不明なままであり、根本的な治療法や予防法の確立には至っていない。本研究の目的は、3MC症候群で生じる病態やその発症機序を明らかにすることで、治療法や予防法開発の糸口となる知見を得るところにある。本研究成果では、3MC症候群の発症に別のコレクチンCL-L1も関与する可能性があることを示唆することができた。この成果は、本疾患の将来的な治療法、予防法開発において有用な情報となる可能性が考えられる。
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