Study on the involvement of collectin CL-K1 in the pathogenesis of 3MC syndrome and elucidation of its molecular mechanism

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19045
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Asahikawa Medical College
• Principal Investigator: Matsuda Yasuyuki 旭川医科大学, 医学部, 助教 (10532252)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: コレクチン / 3MC症候群 / 発生 / 自然免疫

Outline of Final Research Achievements

The association between the gene defect of collectin CL-K1 and the pathology of 3MC syndrome has been found, suggesting that CL-K1 may be involved in growth and development. The purpose of this study is to elucidate the pathogenesis of 3MC syndrome in order to explore the possibility of establishing a medical treatment for it. I found that CL-K1 interacts with collectin CL-L1, suggesting that CL-L1 may also be related to the pathogenesis of 3MC syndrome.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

3MC症候群の発症原因は不明なままであり、根本的な治療法や予防法の確立には至っていない。本研究の目的は、3MC症候群で生じる病態やその発症機序を明らかにすることで、治療法や予防法開発の糸口となる知見を得るところにある。本研究成果では、3MC症候群の発症に別のコレクチンCL-L1も関与する可能性があることを示唆することができた。この成果は、本疾患の将来的な治療法、予防法開発において有用な情報となる可能性が考えられる。