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Development of glycobiological markers specific for normal mesothelium and mesothelioma.

Research Project

Project/Area Number 16K19078
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionUniversity of Fukui

Principal Investigator

Sakai Yasuhiro  福井大学, 学術研究院医学系部門, 特命助教 (20754394)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords硫酸化糖鎖 / 悪性中皮腫 / 呼吸器 / 糖鎖病理学
Outline of Final Research Achievements

We discovered that 6-sulfo sialic lactosamine (sLacNAc) is expressed on normal mesothelial cells and malignant mesothelioma cells by immunohistochemistry, high-performance liquid chromatography, and mass spectrometry. 6-sulfo sLacNAc is identified in various histological types of malignant mesothelioma; thus, the marker recognizing 6-sulfo sLacNAc is very useful to diagnose malignant mesothelioma pathologically. Moreover, some additional animal experiments revealed that this glycostructure is biosynthesized by some sulfotransferases including KSGal6ST, GlcNAc6ST-1, and GlcNAc6ST-2. This glycobiological findings include new aspects of the distribution of sulfated glycans.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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