| Project/Area Number |
16K19078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | University of Fukui |
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Principal Investigator |
Sakai Yasuhiro 福井大学, 学術研究院医学系部門, 特命助教 (20754394)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 硫酸化糖鎖 / 悪性中皮腫 / 呼吸器 / 糖鎖病理学 |
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| Outline of Final Research Achievements |
We discovered that 6-sulfo sialic lactosamine (sLacNAc) is expressed on normal mesothelial cells and malignant mesothelioma cells by immunohistochemistry, high-performance liquid chromatography, and mass spectrometry. 6-sulfo sLacNAc is identified in various histological types of malignant mesothelioma; thus, the marker recognizing 6-sulfo sLacNAc is very useful to diagnose malignant mesothelioma pathologically. Moreover, some additional animal experiments revealed that this glycostructure is biosynthesized by some sulfotransferases including KSGal6ST, GlcNAc6ST-1, and GlcNAc6ST-2. This glycobiological findings include new aspects of the distribution of sulfated glycans.
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