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Developing novel treatment of refractory cancer by targeting Liver X Receptor and its metabolism related gene

Research Project

Project/Area Number 16K19083
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionDokkyo Medical University (2017)
Fukushima Medical University (2016)

Principal Investigator

Kashiwagi Korehito  獨協医科大学, 医学部, 助教 (50722451)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords癌代謝 / 核内受容体 / 難治性癌 / がん代謝 / 難治性がん / 癌 / 病理学
Outline of Final Research Achievements

We investigated of expression of Liver X Receptor (LXRα/β) in normal and refractory cancer tissues of the human lung and pancreas. The result showed that LXRβ was expressed in the
various epithelial cells of normal lung and pancreas tissues. Similarly, LXRβ was expressed in the refractory cancer tissues. We next examined the efficacy of LXR targeted drug against refractory cancer cell lines, but its positive results could not be obtained.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2018 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Expression of liver X receptors in normal and refractory carcinoma tissues of the human lung and pancreas2018

    • Author(s)
      Korehito Kashiwagi, Mai Yanagida, Daiki Matsui, Mizuko Tanaka, Kotaro Sugimoto, Honglei Chen, Naoki Ichikawa-Tomikawa, Shigeru Marubashi, Hiroyuki Suzuki, Hideki Chiba
    • Journal Title

      Histology and Histopathology

      Volume: 33 Pages: 497-505

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 難治性がんにおけるLiver X 受容体の発現2016

    • Author(s)
      柳田真衣, 柏木維人, Honglei Chen, 冨川直樹, 田中瑞子, 千葉英樹
    • Organizer
      日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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