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Study of aging-related glycan factors for the treatment and prevention of elderly heart disease

Research Project

Project/Area Number 16K19098
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

Itakura Yoko  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30582746)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords老化 / 心臓 / 組織 / 糖鎖 / 心血管 / 糖鎖プロファイル / 心疾患
Outline of Final Research Achievements

Elderly cardiac disease makes increase various risks, so the appropriate treatment is essential under mild condition. Identifying molecular changes in cardiac tissue can bring about a development the early diagnosis and appropriate therapy for age-related heart failure. This study was investigated the glycan localization of cardiac tissue in normal mice and the alteration with aging. The cardiac tissue with different age was analyzed using evanescent-filed lectin microarray and stained with some lectins. In consequent, it was found that some glycans changed in papillary muscle and left ventricular wall with aging. The fibrosis in normal mice hearts increased gradually. The timing of their molecular changes was different between female and male mice. It is essential that substantive implications of glycans are revealed by analysis for glycan changes during aging. To show the age-related change in mouse would be helpful for identifying a turning point of disease and aging for human.

Academic Significance and Societal Importance of the Research Achievements

正常マウスの心臓において、雌雄どちらも加齢に伴い糖鎖に示される分子変化に加え、組織変化が領域ごとに生じること、そしてその変化の時期にはわずかに違いが存在することが示唆された。このような変化は領域特異的に生じる疾患と何らかの関係性が存在すると予想される。本研究成果は、高齢化に伴う心疾患患者の予防ならびに治療へと貢献することで、健康で機能的な生活を確保するために重要な役割を果たすと考えられる。今後は、より詳細な分子変化と各心疾患との関連性を明確にして、高齢者における疾患予防への発展を目指す。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2020 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 7 results) Book (1 results)

  • [Journal Article] Comparison of functional glycans between cancer stem cells and normal stem cells.2019

    • Author(s)
      Sasaki N, Itakura Y, Gomi F, Hirano K, Toyoda M, Ishiwata T.
    • Journal Title

      Histol Histopathol.

      Volume: 34 Pages: 995-995

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gangliosides Contribute to Vascular Insulin Resistance2019

    • Author(s)
      Sasaki Norihiko、Itakura Yoko、Toyoda Masashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 8 Pages: 1819-1819

    • DOI

      10.3390/ijms20081819

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Senescence and glycoconjugate research toward development of prevention and therapeutic method for senescence-associated diseases2018

    • Author(s)
      佐々木紀彦、板倉陽子、豊田雅士
    • Journal Title

      生化学

      Volume: 90 Issue: 5 Pages: 719-723

    • DOI

      10.14952/SEIKAGAKU.2018.900719

    • NAID

      40021722804

    • ISSN
      0037-1017
    • Year and Date
      2018-10-25
    • Related Report
      2018 Research-status Report
  • [Journal Article] Qualitative and quantitative alterations in intracellular and membrane glycoproteins maintain the balance between cellular senescence and human aging2018

    • Author(s)
      Itakura Yoko、Sasaki Norihiko、Toyoda Masashi
    • Journal Title

      Aging

      Volume: 10 Issue: 8 Pages: 2190-2208

    • DOI

      10.18632/aging.101540

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Alteration of glycans localization with cellular senescence and human aging2019

    • Author(s)
      Itakura Y, Sasaki N, Toyoda M.
    • Organizer
      International Glycoconjugate Organization
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞および個体老化に伴う細胞の品質保持に関わる糖鎖変化の解析2019

    • Author(s)
      板倉 陽子、佐々木 紀彦、豊田 雅士
    • Organizer
      第42回日本基礎老化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] H19 long non-coding RNA contributes to the metastasis of pancreatic cancer cells by regulating cell adhesion2019

    • Author(s)
      Norihiko Sasaki, Masashi Toyoda, Hisashi Yoshimura, Yoko Matsuda, Tomio Arai, Yoko Itakura, Fujiya Gomi, Junko Aida, Toshiyuki Ishiwata.
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Metastasis-promoting role of H19 long non-coding RNA in pancreatic cancer cells2019

    • Author(s)
      Norihiko Sasaki, Masashi Toyoda, Hisashi Yoshimura, Yoko Matsuda, Tomio Arai, Yoko Itakura, Fujiya Gomi, Junko Aida, Toshiyuki Ishiwata
    • Organizer
      The American Association for Cancer Research Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト冠状動脈内皮細胞の老化に対するラパマイシンの効果について2019

    • Author(s)
      佐々木 紀彦、板倉 陽子、 豊田 雅士
    • Organizer
      第27回日本血管生物医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cardiac tissue glycome mapping using lectin microarray for heart failure cell therapy2018

    • Author(s)
      Itakura Y, Kikkawa Y, Murakami Y, Kuno A, Nagai-Okatani C, Sasaki N, Toyoda M.
    • Organizer
      JAACT2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparative analysis of glycan alterations in intracellular and membrane glycoproteins with cellular senescence and human aging2018

    • Author(s)
      Itakura Y, Sasaki N, Toyoda M
    • Organizer
      10th ACGG Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] レクチンマイクロアレイ法を用いたマウス心臓組織のグライコームマッピング2018

    • Author(s)
      板倉 陽子、吉川 友里香、村上 維菜、豊田 雅士
    • Organizer
      第7回日本比較病理学研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 細胞老化および個体老化を示す細胞表層糖鎖の変化による老化指標の解析2017

    • Author(s)
      板倉 陽子、佐々木 紀彦、豊田 雅士
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 細胞と個体がもたらす老化に伴う糖鎖の変化2017

    • Author(s)
      板倉 陽子、佐々木 紀彦、豊田 雅士
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知市文化プラザ かるぽーと(高知県高知市)
    • Year and Date
      2017-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] Comparison of membrane with cytoplasmic glycan profile changing with cellular senescence and human aging.2017

    • Author(s)
      Itakura Y, Sasaki N, Toyoda M
    • Organizer
      24th International Symposium on Glycoconjugates
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel features of sugar-binding properties of hevein family chitin-binding proteins.2017

    • Author(s)
      Itakura Y, Nakamura-Tsuruta S, Kominami J, Tateno H, Hirabayashi J
    • Organizer
      24th International Symposium on Glycoconjugates
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The cell surface and intracellular glycan profiling with the cellular senescence and the human aging.2017

    • Author(s)
      Itakura Y, Sasaki N, Toyoda M
    • Organizer
      Keystone Symposia Aging and Mechanisms of Aging-Related Disease
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] Biomedical Gerontology2020

    • Author(s)
      板倉 陽子
    • Total Pages
      4
    • Publisher
      日本基礎老化学会
    • Related Report
      2019 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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