The role of mitochondrial fission protein DRP1 in intestinal tumorigenesis

• Project/Area Number: 16K19110
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: The University of Tokyo (2018); Tokyo Women's Medical University (2016-2017)
• Principal Investigator: Inoue-Yamauchi Akane 東京大学, 医科学研究所, 助教 (90541970)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ミトコンドリア / 腫瘍 / がん

Outline of Final Research Achievements

To develop the new therapeutic approaches targeting mitochondrial dynamics, I focused on mitochondrial fission factor DRP1, which is reported to regulate survival of colorectal cancer cell lines. Intestinal tumor mouse model lacking DRP1 specifically in intestinal epithelial cells however develop tumors that was comparable to wild-type control mice.

Academic Significance and Societal Importance of the Research Achievements

近年の研究成果により、ミトコンドリア形態の腫瘍制御への関与が明らかになりつつある。しかしながらそれらの知見の多くは癌細胞レベルの解析にとどまっている。本研究は、腸管腫瘍を自然発症するマウスモデルを用い、ミトコンドリア形態による腫瘍制御を個体レベルで検討した点において意義深い。

Research Products

• [Journal Article] Targeting the Differential Addiction to Anti-apoptotic BCL-2 Family for Cancer Therapy (2017)
  • Author(s): Akane Inoue-Yamauchi, Paul Jeng, Kwanghee Kim, Hui-Chen Chen, Kota Ishizawa, Sylvia Jebiwott , Maria Pietanza, Mark Kris, James Hsieh, Emily Cheng.
  • Journal Title: Nature Communication Volume: 8 Issue: 1 Pages: 1-14
  • DOI: 10.1038/ncomms16078
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis (2017)
  • Author(s): Inoue-Yamauchi Akane、Itagaki Hiroko、Oda Hideaki
  • Journal Title: Carcinogenesis Volume: 39 Issue: 1 Pages: 28-35
  • DOI: 10.1093/carcin/bgx112
• [Presentation] Targeting the BCL-2 family in small cell lung caner (2016)
  • Author(s): Akane Inoue-Yamauchi, Paul Jeng, Kwanghee Kim, Hui-Chen Chen, Song Han, Yogesh Tengarai Ganesan, Yiyu Dong, Sylvia Jebiwott, James J. Hsieh and Emily H. Cheng
  • Organizer: The 107th Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: New Orleans (USA)
  • Year and Date: 2016-04-16
  • Int'l Joint Research