Exploring the small molecule inhibitors that specifically block the intracellular signal perturbation induced by Helicobacter pylori CagA oncoprotein
| Project/Area Number |
16K19121
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Hayashi Takeru 東京大学, 大学院医学系研究科(医学部), 助教 (10722209)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ヘリコバクター・ピロリ / CagA / 胃発がん / がんタンパク質 / 胃がん / ピロリ菌 / 阻害剤探索 / 感染症 / がん / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
X-ray crystal structure analysis and biochemical analysis revealed the structural mechanism underlying the deregulation of human pro-oncogenic phosphatase SHP2 by Helicobacter pylori virulence factor CagA at the atomic level. Based on the structural information, I then explored small-molecular inhibitors that can specifically block CagA-SHP2 interaction. Chemical screening using multiple compound libraries identified several candidates of the inhibitor for CagA-mediated SHP2 deregulation. This study is expected to be a research base leading to the innovative clinical application for prevention and early intervention of gastric cancer caused by H. pylori infection.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Differential mechanisms for SHP2 binding and activation are exploited by geographically distinct Helicobacter pylori CagA Oncoproteins.2017
Author(s)
Hayashi, H., Senda, M., Suzuki, N., Nishikawa, H., Ben, C., Tang, C., Nagase, L., Inoue, K., Senda, T. and Hatakeyama, M.
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Journal Title
Cell Rep
Volume: 20
Issue: 12
Pages: 2876-2890
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Structural insights into the mechanism underlying activation of SHP2 by the Helicobacter pylori CagA oncoprotein.2017
Author(s)
Hayashi, T., Senda, M., Suzuki, N., Inoue, K., Nagase, L., Nishikawa, H., Senda, T., Hatakeyama, M.
Organizer
Europhosphatase 2017
Related Report
Int'l Joint Research
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