| Project/Area Number |
16K19122
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Bacteriology (including mycology)
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
Kiga Kotaro 自治医科大学, 医学部, 講師 (90738246)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ピロリ菌 / sRNA / 酸化ストレス / ノンコーディングRNA / チオレドキシン / 胃がん / 病原性 / Helicobacter pylori / bacteria / non-coding RNA / pathogenicity |
|---|
| Outline of Final Research Achievements |
Chronic infection of Helicobacter pylori is closely related to the onset of gastritis, gastric ulcer, gastric cancer and MALT lymphoma. In this study, we found that a small RNA (sRNA) contributes to resist cytotoxicity caused by oxidative stress in Helicobacter pylori. Furthermore, we revealed that the sRNA stabilizes the expression of thioredoxin-related genes, which is important for oxidative stress response, by analyzing the gene expression of sRNA-deficient strain of H. pylori. Since knockout strain of the sRNA remarkably decreased the ability of H. pylori to colonise to the stomach, it was suggested that the sRNA is involved in gastric disease caused by H. pylori infection.
|
