| Project/Area Number |
16K19167
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Adachi Yu 国立感染症研究所, 免疫部, 主任研究官 (40749016)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | インフルエンザ / B細胞 / 交差防御抗体 / インフルエンザワクチン / 免疫学 / Ｂ細胞 / ワクチン |
|---|
| Outline of Final Research Achievements |
We previously found that cross-reactive B cells were highly selected in lung germinal centers (GCs) following influenza virus infection. In this study, we identified that an occluded epitope in hemagglutinin (HA) stem region for lung cross-reactive GC B cells. This epitope is occluded in native trimeric HA structure, but is exposed in post-fusion HA structure to occur under low-pH during viral replication. Furthermore, immunization by post-fusion HA antigen induces a class of protective antibody which have broad specificity.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で見出した交差防御抗体は、ヒト記憶B細胞にも存在することからユニバーサルワクチンの新たな標的抗体になると考えられる。さらに、この交差防御抗体を選択可能な構造改変型ワクチン剤形は、現行ワクチンから簡便に作製可能であり、新規ユニバーサルワクチン剤形となることが期待される。
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