Studies on mechanisms and prevention of chemotherapy-induced peripheral neuropathy
| Project/Area Number |
16K19184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 抗がん剤 / 末梢神経障害 / オキサリプラチン / 大腸がん / パクリタキセル / シスプラチン / ボルテゾミブ / フマル酸ジメチル / 抗がん薬 / 副作用（有害事象） |
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| Outline of Final Research Achievements |
Chemotherapy agents such as platinum and taxane frequently cause severe peripheral neuropathy and there is currently no effective strategy to prevent this.
In this study, we found a new drug for prevention of the chemotherapy-induced peripheral neuropathy, using screening system targeting nerve fiber degenerations. Dimethyl fumarate attenuates oxaliplatin-induced peripheral neuropathy without affecting both the anti-tumor activity and the other toxicities of oxaliplatin, in culture cells and rodents.
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Report
(3 results)
Research Products
(4 results)
