| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Chemotherapy agents such as platinum and taxane frequently cause severe peripheral neuropathy and there is currently no effective strategy to prevent this.
In this study, we found a new drug for prevention of the chemotherapy-induced peripheral neuropathy, using screening system targeting nerve fiber degenerations. Dimethyl fumarate attenuates oxaliplatin-induced peripheral neuropathy without affecting both the anti-tumor activity and the other toxicities of oxaliplatin, in culture cells and rodents.
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