Investigation of pathogenesis of infant hypothermia-the association between undernutrition during gestation and thermogenesis-
Project/Area Number |
16K19271
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hygiene and public health
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Research Institution | Nagoya University |
Principal Investigator |
HAYASHI Yumi 名古屋大学, 医学系研究科(保健), 講師 (30632707)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 胎生期低栄養 / メタボロミクス / 妊娠期低栄養 / 低体温児 / 制限食 / 衛生 / 環境 / 栄養学 / 行動学 |
Outline of Final Research Achievements |
In this study, we attempted to develop metabolome analysis techniques and create a model mouse of hypothermia to observe body temperature, activity and energy metabolism in infant exposed to undernutrition during gestation. Metabolome analysis methods in liver, muscle and brain were developed using GC/MS/MS and probe electrospray ionization/tandem mass spectrometry (PESI/MS/MS). We tried to create a model mouse of hypothermia induced by food restriction. Mice exposed to food restriction for 10 days or more did not give birth. In 5 days restriction, mice could give birth, but body temperature of the offspring in weaning period was almost same in control group. Therefore, we continue to consider creation of a model mouse of hypothermia.
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Report
(3 results)
Research Products
(20 results)
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[Presentation] Direct drug analysis in serum by probe electrospray ionization/tandem mass spectrometry and its preliminary application to a real-time metabolism study2017
Author(s)
Kei Zaitsu, Yumi Hayashi, Maiko Kusano, Kazuaki Hisatsune, Tomomi Ohara, Tasuku Murata, Hiroki Nakajima, Hiroshi Tanihata, Hitoshi Tsuchihashi, Tetsuya Ishikawa, Akira Ishii
Organizer
The 9th Annual European Congress of the Association for Mass Spectrometry: Application to the Clinical Lab(MSACL 2017 US)
Place of Presentation
Palm Springs Renaissance Hotel and Convention Center, Palm Springs, CA
Year and Date
2017-01-22
Related Report
Int'l Joint Research
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[Presentation] High-throughput Intact Metabolome Analysis of Mouse Biological Specimens by Probe Electrospray Ionization/Tandem Mass Spectrometry (PESI/MS/MS). 65th Conference of American Society for Mass Spectrometry.2017
Author(s)
Yumi Hayashi, Kei Zaitsu, Tasuku Murata, Shiono Baba, Tomomi Ohara, Stephane Moreau, Maiko Kusano, Hiroki Nakajima, Hiroshi Tanihata, Hitoshi Tsuchihashi, Akira Ishii, Tetsuya Ishikawa.
Organizer
65th Conference of American Society for Mass Spectrometry
Related Report
Int'l Joint Research
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[Presentation] Development of an in vivo real-time monitoring system using probe electrospray ionization/tandem mass spectrometry (PESI/MS/MS) and its preliminary applications.2017
Author(s)
Kei Zaitsu, Yumi Hayashi, Tasuku Murata, Tomomi Ohara, Stephane Moreau, Maiko Kusano, Hiroki Nakajima, Hiroshi Tanihata, Hioshi Tsuchihashi, Tetsuya Ishikawa, Akira Ishii.
Organizer
65th Conference of American Society for Mass Spectrometry.
Related Report
Int'l Joint Research
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[Presentation] Rapid-fire direct metabolome analysis by probe electrospray ionization/tandem mass spectrometry: its preclinical applications to validate the methods.2017
Author(s)
Yumi Hayashi, Kei Zaitsu, Tasuku Murata, Tomomi Ohara, Kenta Kondo, Maiko Kusano, Koretsugu Ogata, Hitoshi Tsuchihashi, Hiroshi Tanihata, Akira Ishii, Tetsuya Ishikawa .
Organizer
The 4th Annual European Congress of the Association for Mass Spectrometry: Application to the Clinical Lab(MSACL 2017 EU)
Related Report
Int'l Joint Research
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[Presentation] Direct and rapid analysis of drugs in serum by probe electrospray ionization tandem mass spectrometry (PESI/MS/MS).2017
Author(s)
Tomomi Ohara, Kei Zaitsu, Yumi Hayashi, Maiko Kusano, Kazuaki Hisatsune, Tasuku Murata, Stephane Moreau ,Hiroki Nakajima, Hiroshi Tanihata, Hitoshi Tsuchihashi, Tetsuya Ishikawa, Akira Ishii.
Organizer
15th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology
Related Report
Int'l Joint Research
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[Presentation] Intact metabolome analysis of mice biological tissues by probe electrospray ionization-tandem mass spectrometry and its preliminary application to real-time analysis.2016
Author(s)
Kei Zaitsu, Yumi Hayashi, Tasuku Murata, Hiroki Nakajima, Tetsuya Ishikawa, Maiko Kusano, Hitoshi, Tsuchihashi, Akira Ishii.
Organizer
64th Conference of American Society for Mass Spectrometry.
Place of Presentation
San Antonio, TX, USA
Year and Date
2016-06-05
Related Report
Int'l Joint Research
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