| Project/Area Number |
16K19330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Chiba University (2017)
The University of Tokyo (2016) |
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Principal Investigator |
Ryo Nakagawa 千葉大学, 大学院医学研究院, 特任研究員 (60594596)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自己免疫性肝疾患 / Ras阻害剤 / リンパ球 / 慢性肝炎 / CD4+T細胞 / PBC / AIH / N-RAS / 原発性胆汁性肝硬変 |
|---|
| Outline of Final Research Achievements |
To develop a treatment for chronic liver diseases, I study about Ras-inhibitors. Then the autoimmune liver disease, especially primary biliary cholangitis (PBC) is seemed to be adopted to Ras-inhibitor therapy. In PBC-CD4+ T cells, upregulated N-Ras induced inflammatory cytokines. Then Ras-inhibitors suppressed inflammatory cytokines from CD4+ T cells by regulating N-Ras. Therefor, Ras-inhibitors could be an attractive and novel therapeutic option for PBC.
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