Development of Ras Inhibitory Therapy for Chronic Liver Diseases
Project/Area Number |
16K19330
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Chiba University (2017) The University of Tokyo (2016) |
Principal Investigator |
Ryo Nakagawa 千葉大学, 大学院医学研究院, 特任研究員 (60594596)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 自己免疫性肝疾患 / Ras阻害剤 / リンパ球 / 慢性肝炎 / CD4+T細胞 / PBC / AIH / N-RAS / 原発性胆汁性肝硬変 |
Outline of Final Research Achievements |
To develop a treatment for chronic liver diseases, I study about Ras-inhibitors. Then the autoimmune liver disease, especially primary biliary cholangitis (PBC) is seemed to be adopted to Ras-inhibitor therapy. In PBC-CD4+ T cells, upregulated N-Ras induced inflammatory cytokines. Then Ras-inhibitors suppressed inflammatory cytokines from CD4+ T cells by regulating N-Ras. Therefor, Ras-inhibitors could be an attractive and novel therapeutic option for PBC.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] miR-425 regulates inflammatory cytokine production in CD4+ T cells via N-Ras upregulation in primary biliary cholangitis2017
Author(s)
Ryo Nakagawa, Ryosuke Muroyama, Chisato Saeki, Kaku Goto, Yoshimi Kaise, Kazuhiko Koike, Masanori Nakano, Yasuo Matsubara, Keiko Takano, Sayaka Ito, Masayuki Saruta, Naoya Kato'Correspondence information about the author Naoya KatoEmail the author Naoya Kato, Mikio Zeniya
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Journal Title
Journal of Hepatology
Volume: 印刷中
Issue: 6
Pages: 1223-1230
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] DECREASED MIR-425 INDUCED INFLAMMATORY CYTOKINE PRODUCTION VIA N-RAS UPREGULATION IN CD4+ T CELLS OF PRIMARY BILIAR CHOLANGITIS2016
Author(s)
Ryo Nakagawa, Ryosuke Muroyama, Kazuhiko Koike, Chisato Saeki, Sayaka Ito, Sayuri Morimoto, Kaku Goto, Yasuo Matsubara, Naoya Kato, Mikio Zeniya
Organizer
The International Liver Congress2016, EASL
Place of Presentation
Barcelona, Spain
Year and Date
2016-04-13
Related Report
Int'l Joint Research