Pancreatic congestion in liver cirrhosis correlates with impaired insulin secretion

• Project/Area Number: 16K19350
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: Kuroda Taira 愛媛大学, 医学系研究科, 助教 (10771876)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 肝性糖尿病 / 膵うっ血 / 内分泌機能低下 / 門脈圧亢進症 / インスリン分泌低下 / 肝硬変 / 内分泌機能障害

Outline of Final Research Achievements

The aim of our study was to clarify pathogenesis of hepatogenous diabetes. Using rat model with liver cirrhosis, we showed portal hypertension caused congestion in the pancreas. Expression of HIF-1α in the pancreatic islet cell was significantly more in liver cirrhosis group than that of control group, whereas insulin expression was less. Furthermore, using shear wave elastography and contrast-enhanced ultrasound, we demonstrated degree of the pancreatic congestion and stiffness was significant and insulin secretion was diminished in patients with liver cirrhosis compared to control group. These results suggest hypoxia due to pancreatic congestion contributes to insufficiency of insulin secretion in liver cirrhosis.

Research Products

• [Journal Article] Differences in the risk of fatty liver for onset of impaired fasting glucose according to baseline plasma glucose levels (2017)
  • Author(s): Miyake T, Hirooka M, Yoshida O, Furukawa S, Kumagi T, Koizumi M, Yamamoto S, Kuroda T, Arimitsu E, Takeshita E, Abe M, Kitai K, Matsuura B, Hiasa Y
  • Journal Title: J Gastroenterol Volume: 52 Issue: 2 Pages: 237-244
  • DOI: 10.1007/s00535-016-1234-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma. (2017)
  • Author(s): Ohno Y, Koizumi M, Nakayama H, Watanabe T, Hirooka M, Tokumoto Y, Kuroda T, Abe M, Fukuda S, Higashiyama S, Kumagi T, Hiasa Y.
  • Journal Title: PLoS One. Volume: 12 Issue: 5 Pages: 0177343-0177343
  • DOI: 10.1371/journal.pone.0177343
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of chemotherapy in elderly patients with unresectable pancreatic cancer: a multicenter review of 895 patients. (2017)
  • Author(s): Kuroda T, Kumagi T, Yokota T, Azemoto N, Hasebe A, Seike H, Nishiyama M, Inada N, Shibata N, Miyata H, Kawamura T, Imai Y, Ueno-Toshimori A, Tanaka Y, Terao T, Imamura Y, Koizumi M, Yamanishi H, Ohno Y, Hiasa Y; Ehime Pancreato-Cholangiology (EPOCH) Study Group.
  • Journal Title: BMC Gastroenterol. Volume: 17 Issue: 1 Pages: 66-66
  • DOI: 10.1186/s12876-017-0623-8
  • Peer Reviewed / Open Access
• [Presentation] HBV・HCV慢性肝疾患患者が受ける肝細胞癌サーベイランスが膵癌診断に及ぼす影響 (2017)
  • Author(s): 今村 良樹, 熊木 天児, 寺尾 孝志, 横田 智行, 畔元 信明, 田中 良憲, 木阪 吉保, 芝田 直純, 丹下 和洋, 行本 敦, 宮田 英樹, 西山 麻里, 黒田 太良, 小泉 光仁, 大野 芳敬, 石井 浩, 日浅 陽一, 愛媛胆膵疾患(EPOCH)研究グループ
  • Organizer: 日本消化器病学会
• [Presentation] 自己免疫性膵炎に対する診療の現状と長期予後 愛媛県における自己免疫性膵炎の診療実態およびIgG4陰性自己免疫性膵炎の臨床的特徴 (2017)
  • Author(s): 大野 芳敬, 熊木 天児, 横田 智行, 宮田 英樹, 田中 良憲, 川崎 敬太郎, 多田 藤政, 村上 英広, 畔元 信明, 小泉 光仁, 黒田 太良, 今村 良樹, 日浅 陽一
  • Organizer: 日本膵臓学会