| Project/Area Number |
16K19355
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
SUE Soichiro 横浜市立大学, 附属病院, 助教 (00738619)
|
|---|
| Research Collaborator |
MAEDA Shin
SHIBATA Wataru
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|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ISX / Helicobacter pylori / 胃発癌 / 腸上皮化生 / ヘリコバクター・ピロリ / MNU |
|---|
| Outline of Final Research Achievements |
Intestine-specific homeobox, ISX, is a homeobox gene and express intestine specific. ISX don’t express in normal stomach and Helicobacter pylori infection induce ISX expression in stomach via NF-κB signaling. ISX expressing gastric cancer generate in the ISX expressing gastric mucosa, and ISX knockout in gastric carcinogenesis mouse model suppressed gastric carcinogenesis. ISX knockdown in ISX expressing gastric cancer suppressed intestinal metaplasia marker and gastric cancer growth. ISX expression increased in organoids cultured from Helicobacter-infected mouse and human gastric mucosa. ISX plays an important role in gastric carcinogenesis and tumor growth, indicating that ISX may become a molecular target for gastric carcinogenesis and gastric cancer.
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