Lifestyle intervention for improvement of the outcome after catheter ablation for atrial fibrillation

• Project/Area Number: 16K19399
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Nagoya University
• Principal Investigator: Yanagisawa Satoshi 名古屋大学, 医学系研究科, 寄附講座助教 (30768578)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 心房細動 / カテ―テルアブレーション / 運動機能 / 運動療法 / アブレーション / カテーテルアブレーション / メタボリックシンドローム / 動脈硬化 / 生活習慣病

Outline of Final Research Achievements

The present study was aimed to evaluate physical activities and motor function by using an accelerometer in patients who underwent catheter ablation for atrial fibrillation. After the follow-up period of 6 months, mean daily steps and maximum daily steps were increased from pre-ablation to post-ablation procedure. Moreover, the exercise intensity was increased after the ablation. The improvement of physical activities and motor function was found in the early phase after the ablation procedure. The results may be explained by the effect of suppressing atrial fibrillation and improvement of cardiac hemodynamics.

Academic Significance and Societal Importance of the Research Achievements

本研究は、心房細動アブレーション治療前後の運動機能や活動能力を、活動量計を用いて客観的に評価したものである。その成果として、活動量や運動能力の改善が、アブレーション術後比較的早期から改善していることが判明した。心房細動カテーテルアブレーション治療後では血管穿刺や自律神経への影響もあるが、運動機能と活動量への影響が早期に認められたことは、術後のADL向上や早期社会復帰への指標となりえることが考えられる。

Research Products

• [Journal Article] Uninterrupted Direct Oral Anticoagulant and Warfarin Administration in Elderly Patients Undergoing Catheter Ablation for Atrial Fibrillation (2018)
  • Author(s): Yanagisawa Satoshi、Inden Yasuya、Fujii Aya、Ando Monami、Funabiki Junya、Murase Yosuke、Takenaka Masaki、Otake Noriaki、Ikai Yoshihiro、Sakamoto Yusuke、Shibata Rei、Murohara Toyoaki
  • Journal Title: JACC: Clinical Electrophysiology Volume: 4 Issue: 5 Pages: 592-600
  • DOI: 10.1016/j.jacep.2018.02.013
  • Peer Reviewed
• [Journal Article] 心房細動カテーテルアブレーション治療の周術期抗凝固療法 (2018)
  • Author(s): 柳澤 哲
  • Journal Title: BIO Clinica, TOPICS Volume: 33 Pages: 36-41
• [Journal Article] Renal function and risk of stroke and bleeding in patients undergoing catheter ablation for atrial fibrillation: Comparison between uninterrupted direct oral anticoagulants and warfarin administration (2018)
  • Author(s): Yanagisawa Satoshi、Inden Yasuya、Fujii Aya、Ando Monami、Funabiki Junya、Murase Yosuke、Takenaka Masaki、Otake Noriaki、Ikai Yoshihiro、Sakamoto Yusuke、Shibata Rei、Murohara Toyoaki
  • Journal Title: Heart Rhythm. Volume: 15 Issue: 3 Pages: 348-354
  • DOI: 10.1016/j.hrthm.2017.10.033
  • Peer Reviewed
• [Journal Article] Assessment of autonomic nervous system modulation after novel catheter ablation techniques for atrial fibrillation using multiple short-term electrocardiogram recordings (2018)
  • Author(s): Yanagisawa Satoshi、Inden Yasuya、Fujii Aya、Kamikubo Yosuke、Kanzaki Yasunori、Ando Monami、Funabiki Junya、Murase Yosuke、Takenaka Masaki、Otake Noriaki、Ikai Yoshihiro、Sakamoto Yusuke、Shibata Rei、Murohara Toyoaki
  • Journal Title: J Interv Card Electrophysiol. Volume: 51 Issue: 1 Pages: 35-44
  • DOI: 10.1007/s10840-017-0295-x
  • Peer Reviewed
• [Journal Article] Vagal response in cryoballoon ablation of atrial fibrillation and autonomic nervous system: Utility of epicardial adipose tissue location (2017)
  • Author(s): Yanagisawa Satoshi、Inden Yasuya、Mizutani Yoshiaki、Fujii Aya、Kamikubo Yosuke、Kanzaki Yasunori、Ando Monami、Funabiki Junya、Murase Yosuke、Takenaka Masaki、Otake Noriaki、Hattori Tetsuyoshi、Shibata Rei、Murohara Toyoaki
  • Journal Title: J Arrhythm. Volume: 33 Issue: 4 Pages: 275-282
  • DOI: 10.1016/j.joa.2017.03.001
  • Peer Reviewed / Open Access
• [Journal Article] Impaired renal function is associated with recurrence after cryoballoon catheter ablation for paroxysmal atrial fibrillation: A potential effect of non-pulmonary vein foci. (2017)
  • Author(s): Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.
  • Journal Title: J Cardiol. Volume: 69 Issue: 1 Pages: 3-10
  • DOI: 10.1016/j.jjcc.2016.07.008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect and Significance of Early Reablation for the Treatment of Early Recurrence of Atrial Fibrillation After Catheter Ablation. (2016)
  • Author(s): Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.
  • Journal Title: Am J Cardiol. Volume: 118 Issue: 6 Pages: 833-841
  • DOI: 10.1016/j.amjcard.2016.06.045
  • Peer Reviewed
• [Journal Article] Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation: an observational study from the outpatient clinic. (2016)
  • Author(s): Yanagisawa S, Inden Y, Yoshida N, Kato H, Miyoshi-Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.
  • Journal Title: Heart Vessels. Volume: 31 Issue: 9 Pages: 1553-1561
  • DOI: 10.1007/s00380-015-0765-y
  • Peer Reviewed
• [Journal Article] An ECG Index of P-Wave Force Predicts the Recurrence of Atrial Fibrillation after Pulmonary Vein Isolation. (2016)
  • Author(s): Kanzaki Y, Inden Y, Ando M, Kamikubo Y, Ito T, Mizutani Y, Kato H, Fujii A, Yanagisawa S, Hirai M, Murohara T.
  • Journal Title: Pacing Clin Electrophysiol. Volume: 39 Issue: 11 Pages: 1191-1197
  • DOI: 10.1111/pace.12956
  • Peer Reviewed
• [Presentation] Electrocardiogram Characteristics of the P-Wave Associate with Successful Pulmonary Vein Isolation: Significance of Changes in P-Wave Duration and Notched P-Wave (2019)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Sakamoto Y, Mamiya K, Okamoto H, Tomomatsu T, Shibata R, Murohara T.
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Catheter Ablation for Manifest Wolff-Parkinson-White Syndrome Using Ultra-High-Resolution Three-Dimensional Mapping System: A Potential Benefit to Identify Complex Accessory Pathway (2019)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Sakamoto Y, Mamiya K, Okamoto H, Tomomatsu T, Shibata R, Murohara T.
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Uninterrupted Direct Oral Anticoagulant and Warfarin Administration in Elderly Patients Undergoing Catheter Ablation for Atrial Fibrillation: A Comparison with Younger Patients. (2018)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Sakamoto Y, Shibata R, Murohara T.
  • Organizer: The Heart Rhythm Society's 39th Scientific Sessions
  • Int'l Joint Research
• [Presentation] Hybrid Therapy with Anti-Arrhythmic Drugs and Ablation in AF Patients Associated with Chronic HF (2018)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Sakamoto Y, Mamiya K, Okamoto H, Tomomatsu T, Shibata R, Murohara T.
  • Organizer: The 11th Asia Pacific Heart Rhythm Society Scientific Session (APHRS 2018)
  • Int'l Joint Research / Invited
• [Presentation] Electrocardiogram characteristics of the P-wave associate with successful pulmonary vein isolation in patients with paroxysmal atrial fibrillation: significance of changes in P-wave duration and notched P-wave. (2018)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Sakamoto Y, Mamiya K, Okamoto H, Tomomatsu T, Shibata R, Murohara T.
  • Organizer: The 11th Asia Pacific Heart Rhythm Society Scientific Session (APHRS 2018)
  • Int'l Joint Research
• [Presentation] Renal function and risk of stroke and bleeding in patients undergoing catheter ablation for atrial fibrillation: comparison between uninterrupted direct oral anticoagulants and warfarin administration. (2018)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Sakamoto Y, Mamiya K, Okamoto H, Tomomatsu T, Shibata R, Murohara T.
  • Organizer: The 11th Asia Pacific Heart Rhythm Society Scientific Session (APHRS 2018)
  • Int'l Joint Research
• [Presentation] Uninterrupted Direct Oral Anticoagulants and Warfarin Administration in Elderly Patients Undergoing Catheter Ablation for Atrial Fibrillation: Comparison with Younger Patients (2018)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Hybrid Therapy of Catheter Ablation and Antiarrhythmic Drug in Patients with Atrial Fibrillation and Chronic Heart Failure (2018)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Assessment of Autonomic Nervous System Modulation after Novel Catheter Ablation Techniques for Atrial Fibrillation Using Multiple Short-Term Electrocardiogram Recordings (2018)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Impaired Renal Function is Associated with Recurrence after Cryoballoon Catheter Ablation for Paroxysmal Atrial Fibrillation (2017)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Kamikubo Y, Kanzaki Y, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他（石川県金沢市）
  • Year and Date: 2017-03-17
• [Presentation] Clinical Course and Outcomes in Patients with Magnetic Resonance Imaging Conditional Pacemaker Implantation (2017)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Kamikubo Y, Kanzaki Y, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他（石川県金沢市）
  • Year and Date: 2017-03-17
• [Presentation] Effect of Vagal Response in Cryoballoon Ablation of Atrial Fibrillation on the Cardiac Autonomic Nerve System (2017)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Kamikubo Y, Kanzaki Y, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他（石川県金沢市）
  • Year and Date: 2017-03-17
• [Presentation] Periprocedural Antiarrhythmic Drug Use in Patients Undergoing Catheter Ablation for atrial fibrillation: Hybrid therapy with AAD and ablation in AF patients associated with chronic heart failure. (2017)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Kamikubo Y, Kanzaki Y, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: The 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS 2017); the Annual Meeting of the Japanese Heart Rhythm Society 2017 (JHRS)
  • Int'l Joint Research / Invited
• [Presentation] Assessment of Autonomic Nervous System Modulation after Novel Catheter Ablation Techniques for Atrial Fibrillation Using Multiple Short-Term Electrocardiogram Recordings. (2017)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Kamikubo Y, Kanzaki Y, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: The 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS 2017); the Annual Meeting of the Japanese Heart Rhythm Society 2017 (JHRS)
  • Int'l Joint Research
• [Presentation] Early Repeat ablation for the Treatment of Early Recurrence after Catheter Ablation of Atrial fibrillation can Improve Recurrence-Free Survival: A Propensity Score-Matched Study. (2017)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Kamikubo Y, Kanzaki Y, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: The 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS 2017); the Annual Meeting of the Japanese Heart Rhythm Society 2017 (JHRS)
  • Int'l Joint Research
• [Presentation] Elevated Red Blood Cell Distribution Width Predicts Recurrence after Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure: Comparison with Non-Heart Failure Patients. (2016)
  • Author(s): Yanagisawa S, Inden Y, Fujii A, Kamikubo Y, Kanzaki Y, Ando M, Murase Y, Funabiki J, Takenaka M, Otake N, Shibata R, Murohara T.
  • Organizer: The 9th Asia Pacific Heart Rhythm Society Scientific Session (APHRS)
  • Place of Presentation: Seoul (Republic Korea)
  • Year and Date: 2016-10-12
  • Int'l Joint Research
• [Presentation] Decrease in B-type natriuretic peptide levels and successful catheter ablation for atrial fibrillation in patients with heart failure: a clinical indicator of reverse remodeling (2016)
  • Author(s): Yanagisawa S, Inden Y, Kato H, Okumura S, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.
  • Organizer: 第63回日本不整脈心電学会学術大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-07-14
• [Presentation] Elevated red blood cell distribution width predicts recurrence after catheter ablation for atrial fibrillation in patients with heart failure: comparison with non-heart failure patients (2016)
  • Author(s): Yanagisawa S, Inden Y, Kato H, Okumura S, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.
  • Organizer: 第63回日本不整脈心電学会学術大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-07-14