The role of JCAD, an adhesion molecule of endothelial cell, in regulating thrombosis

Research Project

Project/Area Number	16K19406
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Cardiovascular medicine
Research Institution	Kobe University
Principal Investigator	Hara Tetsuya 神戸大学, 医学研究科, 特命助教 (70547504)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	深部静脈血栓症 / 深部静脈血栓 / 血栓
Outline of Final Research Achievements	１．We assessed the role of JCAD in the regulation of thrombus formation. Using IVC ligation model, we compared the DVT size between WT mice and JCAD knock out mice. JCAD knock-out mice exhibited significantly larger thrombus size compared to WT mice. 2. We then assessed the molecular mechanism of JCAD in thrombus formation. Western blotting analysis revealed that JCAD regulate the ERK signaling cascade in HUVEC after the VEGF (vascular endothelial growth factor) stimulation.