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The novel therapy of pulmonary hypertension by preventing right heart failure

Research Project

Project/Area Number 16K19409
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionYamaguchi University

Principal Investigator

ONO Makoto  山口大学, 医学部附属病院, 診療助教(4日/週) (50650321)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsカルモジュリン / リアノジン受容体 / 肺高血圧 / Ca2+ ハンドリング / 肺動脈性肺高血圧 / 肺動脈性肺高血圧症 / 右室肥大
Outline of Final Research Achievements

PAH mice and Sham mice were orally administered the Ca leak inhibitor dantrolene, and the right ventricular pressure was measured, the cardiomyocyte size was measured, Ca transient observation, fixed and anti-CaM, anti-GRK 5, anti-HDAC 4, 5, anti Immunostaining was performed with antibodies of -p-HDAC 4, 5. As a result, oral administration of dantrolene did not affect pulmonary artery pressure. In the oral administration group of dantrolene, myocardial cell size was reduced and the hypertrophy was suppressed. Furthermore, reduction of RyR bound CaM was suppressed. From this, it was suggested that dantrolene inhibited the dissociation of CaM from RyR, thus suppressing hypertrophy.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Strict sequential catheter ablation strategy targeting the pulmonary veins and superior vena cava for persistent atrial fibrillation.2018

    • Author(s)
      Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fukuda M, Fumimoto T, Ishiguchi H, Omuro T, Kobayashi S, Yano M.
    • Journal Title

      J Cardiol

      Volume: in press Issue: 2 Pages: 128-134

    • DOI

      10.1016/j.jjcc.2018.01.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.2018

    • Author(s)
      Nishimura S, Yamamoto T, Nakamura Y, Kohno M, Hamada Y, Sufu Y, Fukui G, Nanno T, Ishiguchi H, Kato T, Xu X, Ono M, Oda T, Okuda S, Kobayashi S, Yano M.
    • Journal Title

      Heart Rhythm

      Volume: 印刷中 Issue: 6 Pages: 905-914

    • DOI

      10.1016/j.hrthm.2018.02.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Macroreentrant form of an adenosine 5′-triphosphate sensitive atrial tachycardia arising from the vicinity of the atrioventricular node involving the tricuspid and mitral annuli as its reentrant circuit2017

    • Author(s)
      Ueyama Takeshi、Shimizu Akihiko、Yoshiga Yasuhiro、Ono Makoto、Fumimoto Tomoko、Yano Masafumi
    • Journal Title

      HeartRhythm Case Reports

      Volume: 3 Issue: 6 Pages: 289-293

    • DOI

      10.1016/j.hrcr.2017.03.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inferior J waves in patients with vasospastic angina might be a risk factor for ventricular fibrillation.2017

    • Author(s)
      Fumimoto T, Ueyama T, Shimizu A, Yoshiga Y, Ono M, Kato T, Ishiguchi H, Okamura T, Yamada J, Yano M.
    • Journal Title

      J Cardiol

      Volume: 70 Issue: 3 Pages: 271-277

    • DOI

      10.1016/j.jjcc.2016.12.003

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure.2017

    • Author(s)
      Kato T, Yamamoto T, Nakamura Y, Nanno T, Fukui G, Sufu Y, Hamada Y, Maeda T, Nishimura S, Ishiguchi H, Murakami W, Fukuda M, Xu X, Hino A, Ono M, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M.
    • Journal Title

      Heart Rhythm

      Volume: 14 Issue: 1 Pages: 120-127

    • DOI

      10.1016/j.hrthm.2016.10.019

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Successful cryoballoon pulmonary vein isolation in a patient with situs inversus and dextrocardia2016

    • Author(s)
      Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fumimoto T, Ishiguchi H, Yano M.
    • Journal Title

      J Arrhythm

      Volume: 32 Pages: 493-496

    • Related Report
      2016 Research-status Report
    • Peer Reviewed

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Published: 2016-04-21   Modified: 2019-03-29  

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