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the role of sirt7 in the vascular disease

Research Project

Project/Area Number 16K19411
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionKumamoto University

Principal Investigator

Araki Satoshi  熊本大学, 大学院生命科学研究部(医), 助教 (20706717)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsSirt7 / 血管内皮障害 / 新生内膜 / 動脈硬化 / 炎症 / smooth muscle cell / 血管平滑筋細胞 / 循環器
Outline of Final Research Achievements

Sirt7 expression was increased in various vascular disease mouse models. To identify the role of Sirt7 in vascular diseases, we created a mouse model of vascular wire injury. Sirt7-/- mice showed significant reduced in neointimal formation compared to wild type (WT) mice. In vitro experiments, lack of Sirt7 attenuated serum-induced proliferation and migration of vascular smooth muscle cells (VSMCs). These changes were accompanied by increasing of miRNA 290-295 cluster.

Academic Significance and Societal Importance of the Research Achievements

サーチュインはいわゆる「長寿遺伝子」として知られており,なかでもSirt7 は近年飛躍的に機能解析が進みつつある。「ヒトは血管とともに老いる」と言われるように、血管機能障害や動脈硬化は老化の一つの表現型であり、血管病変におけるSirt7の機能を本研究で明らかにすることで、新たな血管障害に対する治療法の解明につながると考えられる。実際、Sirt7の欠如は血管内皮障害モデルにおける血管新生内膜の造成を抑制しており、Sirt7を抑制することで、冠動脈治療後などの血管内再狭窄の予防につながる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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