Phenotype and biomarkers of the asthma COPD overlap syndrome
| Project/Area Number |
16K19450
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | asthma / Eosinophilic / Smoking / Staphylococcal / 喘息 / 喫煙 / 黄色ブドウ球菌 / 好酸球性炎症 / COPD / アレルギー・ぜんそく |
|---|
| Outline of Final Research Achievements |
At first, the associations of inflammatory cell types and pulmonary function in patients with obstructive airway disease were investigated. We showed that
both eosinophilic and neutrophilic inflammation may be associated with airflow limitation in steroid-naive ex-smokers with asthma.
Next, the effects of the biomarkers on clinical indexes, including eosinophilic inflammation and lung function were assessed in smokers with asthma.The frequency of sensitization to SEs was significantly higher in current, ex-, and never smokers, in decreasing order. In current or ex-smokers with asthma, patients with sensitization to SEs exhibited higher blood eosinophil counts, greater airflow limitation, and more severe disease than those without sensitization to SE. A longer smoking abstinence period was associated with serum specific IgE levels to SEs. We showed that sensitization to SEs may be a marker of eosinophilic inflammation and disease severity in obstructive lung diseases.
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Report
(3 results)
Research Products
(7 results)
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[Presentation] Smoking and Staphylococcus aureus enterotoxin sensitization in adults with asthma2016
Author(s)
Tadao Nagasaki, Hisako Matsumoto, Tsuyoshi Oguma, Isao Ito, Hideki Inoue, Toshiyuki Iwata, Tomoko Tajiri, Yoshihiro Kanemitsu, Yumi Izuhara, Akio Niimi, Michiaki Mishima
Organizer
第65回日本アレルギー学会学術大会
Place of Presentation
東京国際フォーラム
Year and Date
2016-06-17
Related Report
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[Presentation] Both Eosinophilic and Neutrophilic Inflammation were Associated with Pulmonary Function in Ex-smokers with Asthma2016
Author(s)
T. Nagasaki, H. Matsumoto, T. Oguma, H. Inoue, T.Iwata, T. Tajiri, Y. Kanemitsu, Y. Izuhara, H. Sunadome, I. Ito, A. Niimi, M. Mishima
Organizer
American Thoracic Society conference
Place of Presentation
San Francisco
Year and Date
2016-05-13
Related Report
Int'l Joint Research
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