| Project/Area Number |
16K19473
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
NAITO Keisuke 産業医科大学, 医学部, 修練指導医 (80739475)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肺非結核性抗酸菌症 / clone library method / 複数菌感染 / 16S ribosomal RNA / 気管支洗浄液 / 混合感染 / 早期診断 / 16S ribosomalRNA / 網羅的細菌叢解析 |
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| Outline of Final Research Achievements |
NTM was cultured in 55 of 120 patients, and 52 (94.5%) of these 55 patients were positive for the clone library method. Among these 52 patients, BALF samples of 45 (86.5%) patients were occupied with a single phylotype of NTM (mono-phylotype group), and multiple phylotypes were detected (multi-phylotype group) in the rest 7 (13.5%) patients. The multi-phylotype group significantly included more patients with worsening chest CT findings (P =0.048), more patients requiring treatment (P=0.032), and fewer patients responding to antimycobacterial treatment (P=0.016) compared to the mono-phylotype group.
Patients with multi-phylotype NTM group tend to show worsening chest CT findings and lower response to antimycobacterial treatment and symptom improvement.
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