Protective role of magnesium in phosphate toxicity

Research Project

Project/Area Number	16K19487
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Kidney internal medicine
Research Institution	Osaka University
Principal Investigator	Sakaguchi Yusuke 大阪大学, 医学系研究科, 寄附講座助教 (80756817)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	マグネシウム / リン / 慢性腎臓病 / klotho / 腎障害
Outline of Final Research Achievements	Excess phosphate aggravates renal injuries. We have previously reported that magnesium attenuates phosphate-induced tubular cell injuries. Here we studied in vivo effects of magnesium on kidney injuries induced by high-phosphate diet.　We found that increasing dietary magnesium improved kidney injuries caused by high phosphate diet. In addition, downregulation of renal αKlotho expression by high phosphate diet was restored by increasing dietary magnesium intake.

Report

(3 results)