Pathophysiology of speech and voice disorders in Parkinson's disease patients treated with deep brain stimulation
| Project/Area Number |
16K19507
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Nagoya University |
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Principal Investigator |
Takashi Tsuboi 名古屋大学, 医学部附属病院, 医員 (50772266)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | パーキンソン病 / 脳深部刺激療法 / 発話障害 / 治療法 / 視床下核 / 医療・福祉 / 神経科学 / 脳神経疾患 |
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| Outline of Final Research Achievements |
We aimed to reveal the pathophysiology of speech and voice disorders in Parkinson’s disease (PD) patients treated with deep brain stimulation (DBS) and establish the treatment strategies for them. We found that Approximately 90% of PD patients had one or more types of speech and voice disorders (hypokinetic dysarthria, breathy voice, and stuttering) before surgery, which stemmed from PD itself, that Strained voice and spastic dysarthria were the most common DBS-induced speech and voice disorders, and that stuttering and breathy voice can be worsened by STN-DBS in a minority of patients. Additionally, male gender, worse cognitive function especially visuospatial/executive function and memory, worse motor function, and higher dose of anti-parkinsonian drugs are the possible risk factors for stuttering. Further studies are warranted to establish objective evaluation methods of speech and voice disorders and effective treatment strategies.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Articulation Features of Parkinson's Disease Patients with Subthalamic Nucleus Deep Brain Stimulation.2016
Author(s)
Tanaka Y, Tsuboi T, Watanabe H, Kajita Y, Nakatsubo D, Fujimoto Y, Ohdake R, Ito M, Atsuta N, Yamamoto M, Wakabayashi T, Katsuno M, Sobue G.
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Journal Title
J Parkinsons Dis
Volume: 6
Issue: 4
Pages: 811-819
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Longitudinal changes in speech and voice functions after subthalamic stimulation in Parkinson’s disease patients.2017
Author(s)
Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Kawabata K, Hara K, Nakatsubo D, Maesawa S, Kajita Y, Wakabayashi T, Katsuno M and Sobue G.
Organizer
the 21th International Congress of Parkinson's disease and movement disorders
Related Report
Int'l Joint Research
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[Presentation] Longitudinal changes of speech and voice disorders following subthalamic stimulation in Parkinson’s disease patients.2016
Author(s)
Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Kaabata K, Hara K, Ito M, Hirayama M, Fujimoto Y, Kajita Y, Katsuno M, Sobue G.
Organizer
the 20th International Congress of Parkinson's disease and movement disorders
Place of Presentation
Berlin Germany
Year and Date
2016-06-19
Related Report
Int'l Joint Research
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