The enhancement of anti-tumor immune response and application to a therapy with the IDO inhibitor
Project/Area Number |
16K19584
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Nagoya City University |
Principal Investigator |
Masaki Ayako 名古屋市立大学, 大学院医学研究科, 講師 (40648044)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | IDO / Malignant lymphoma / Tumor immunity / 悪性リンパ腫 / 抗腫瘍免疫 / 造血器悪性腫瘍 / 免疫療法 |
Outline of Final Research Achievements |
Indoleamine 2,3-dioxygenase 1 (IDO) is one of enzyme catabolizing tryptophan into the kynurenine pathway, and recognized as an important microenvironmental factor suppressing antitumor immune responses. Quantification of serum Kyn and Trp is useful for predicting prognosis of an individual patients with hematological malignancy, such as adult T-cell leukemia/lymphoma, Hodgkin lymphoma, and follicular lymphoma. Furthermore, it is thought that IDO is an attractive novel cancer immunotherapies target in various hematological malignancy.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Clinical significance of tryptophan catabolism in Hodgkin lymphoma2017
Author(s)
Masaki Ayako、Ishida Takashi、Maeda Yasuhiro、Ito Asahi、Suzuki Susumu、Narita Tomoko、Kinoshita Shiori、Takino Hisashi、Yoshida Takashi、Ri Masaki、Kusumoto Shigeru、Komatsu Hirokazu、Inagaki Hiroshi、Ueda Ryuzo、Choi Ilseung、Suehiro Youko、Iida Shinsuke
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Journal Title
Cancer Science
Volume: 109
Issue: 1
Pages: 74-83
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Prognostic significance of tryptophan catabolism in newly diagnosed Hodgkin Lymphoma2016
Author(s)
Ayako Masaki, Takashi Ishida, Tomoko Narita, Asahi Ito, Shiori Kinoshita, Susumu Suzuki, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Ilseung Choi, Youko Suehiro, Hiroshi Inagaki, Ryuzo Ueda, Shinsuke Iida
Organizer
第75回日本癌学会学術集会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Related Report
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[Presentation] Prognostic significance of tryptophan catabolism in newly diagnosed Hodgkin Lymphoma2016
Author(s)
Ayako Masaki, Takashi Ishida, Yasuhiro Maeda, Tomoko Narita, Asahi Ito, Shiori Kinoshita, Susumu Suzuki, Hisashi Takino, Takashi Yoshida, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Ilseung Choi, Youko Suehiro, Hiroshi Inagaki, Ryuzo Ueda, Shinsuke Iida
Organizer
第78回日本血液学会学術集会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Related Report
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