| Project/Area Number |
16K19591
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Kato Masaru 北海道大学, 大学病院, 助教 (10755896)
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| Research Collaborator |
SUGAWARA Eri 北海道大学, 医学院, 大学院生
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 関節リウマチ / オートファジー / シトルリン化 / 抗原提示 / ビメンチン / 内科 / リウマチ学 |
|---|
| Outline of Final Research Achievements |
This study has clarified that (1) synovial fibroblasts express MHC class II and costimulatory molecules upon stimulation with IFN-gamma, (2) citrullinated vimentin in synovial fibroblasts is recognized by anti-citrullinated peptide antibodies from rheumatoid arthritis patients, (3) citrullinated vimentin binds to MHC class II, and (4) citrullinated vimentin is increased by the induction of autophagy while is decreased by autophagy inhibition. These results are novel findings in the pathogenesis of rheumatoid arthritis, particularly in its autoimmunity, and suggest a role of synovial fibroblasts in the production of anti-citrullinated peptide antibodies through autophagy.
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