• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Sensitization profiles to fruit, vegetable, and pollen allergens among patients with fruit and vegetable allergy

Research Project

Project/Area Number 16K19611
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionClinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital

Principal Investigator

Fukutomi Yuma  独立行政法人国立病院機構(相模原病院臨床研究センター), 診断・治療薬開発研究室, 室長 (30463110)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords食物アレルギー / アレルギー・ぜんそく
Outline of Final Research Achievements

Fruit and vegetable allergies, which are common in adults, are often caused by pollen allergy. However, there is a great diversity of causative pollen, the types of food that induces symptoms, and the allergic symptoms that are induced by food ingestion in patients with fruits and vegetables allergy.
In this study, we analyzed the clinical information of a large number of patients and the results of blood IgE antibody test to allergen components. We found that the diversity of clinical presentation of patients with fruit-vegetable allergies are well-explained by sensitization to three allergen components of PR-10, profilin, and GRP.

Academic Significance and Societal Importance of the Research Achievements

果物野菜アレルギーの複雑性が、三つのアレルゲンコンポーネントへのIgE保有状況の評価を行うことにより、容易に理解できることが明らかになった。この知見は果物野菜アレルギー患者さんの生活指導や食事制限を行う上で極めて重要な情報である。また、本研究から三つのアレルゲンによる病態の原因となる花粉も明らかになったため、アレルゲン免疫療法などの当該疾患に対する根本的治療を行うときにも重要な情報も得られた。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018 2017 2016

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Long-term dynamics of omega-5 gliadin-specific IgE levels in patients with adult-onset wheat allergy2020

    • Author(s)
      Hamada Y, Chinuki Y, Fukutomi Y, Nakatani E, Yagami A, Matsunaga K, Oda Y, Fukunaga A, Adachi A, Hiragun M, Hide M, Morita E
    • Journal Title

      J Allergy Clin Immunol Pract.

      Volume: 8 Issue: 3 Pages: 1149-1151

    • DOI

      10.1016/j.jaip.2019.10.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allergen‐specific IgG4 over time: observation among adults with hydrolyzed wheat protein allergy2019

    • Author(s)
      Fukutomi Yuma、Teruuchi Yuya、Nakatani Eiji、Minami Takafumi、Sasagawa Yoshikiyo、Fukushima Masao、Kamide Yosuke、Sekiya Kiyoshi、Saito Hirohisa、Teshima Reiko、Adachi Reiko、Taniguchi Masami
    • Journal Title

      Allergy

      Volume: 印刷中 Issue: 8 Pages: 1584-1587

    • DOI

      10.1111/all.13866

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regional differences in the prevalence of sensitization to environmental allergens: Analysis on IgE antibody testing conducted at major clinical testing laboratories throughout Japan from 2002 to 20112019

    • Author(s)
      Minami Takafumi、Fukutomi Yuma、Inada Reiko、Tsuda Manabu、Sekiya Kiyoshi、Miyazaki Masaki、Tsuji Fumio、Taniguchi Masami
    • Journal Title

      Allergology International

      Volume: 68 Issue: 4 Pages: 440-449

    • DOI

      10.1016/j.alit.2019.03.008

    • NAID

      130007733131

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Occupational food allergy2019

    • Author(s)
      Fukutomi Yuma
    • Journal Title

      Current Opinion in Allergy and Clinical Immunology

      Volume: 19 Issue: 3 Pages: 243-248

    • DOI

      10.1097/aci.0000000000000530

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hand eczema as a risk factor for food allergy among occupational kitchen workers2018

    • Author(s)
      Minami T, Fukutomi Y, Sekiya K, Akasawa A, Taniguchi M.
    • Journal Title

      Allergology International

      Volume: 67 Issue: 2 Pages: 217-224

    • DOI

      10.1016/j.alit.2017.08.005

    • NAID

      130006721751

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lip b 1 is a novel allergenic protein isolated from the booklouse, Liposcelis bostrychophila2017

    • Author(s)
      Ishibashi O.、Sakuragi K.、Fukutomi Y.、Kawakami Y.、Kamata Y.、Sakurai M.、Nakayama S.、Uchiyama H.、Kobayashi H.、Kojima H.、Inui T.
    • Journal Title

      Allergy

      Volume: 72 Issue: 6 Pages: 918-926

    • DOI

      10.1111/all.13091

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severe or life-threatening asthma exacerbation: patient heterogeneity identified by cluster analysis.2016

    • Author(s)
      Sekiya K, Nakatani E, Fukutomi Y, Kaneda H, Iikura M, Yoshida M, Takahashi K, Tomii K, Nishikawa M, Kaneko N, Sugino Y, Shinkai M, Ueda T, Tanikawa Y, Shirai T, Hirabayashi M, Aoki T, Kato T, Iizuka K, Homma S, Taniguchi M, Tanaka H
    • Journal Title

      Clin Exp Allergy

      Volume: 46(8) Issue: 8 Pages: 1043-1055

    • DOI

      10.1111/cea.12738

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serological diagnosis of allergic bronchopulmonary mycosis: Progress and challenges2016

    • Author(s)
      Fukutomi Y, Tanimoto H, Yasueda H, Taniguchi M.
    • Journal Title

      Allergology International

      Volume: 65 Issue: 1 Pages: 30-36

    • DOI

      10.1016/j.alit.2015.08.004

    • NAID

      130005290247

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 3.Characteristics of the Pru p 7-sensitized fruit-allergic patients, A clinical investigation among Japanese adults2016

    • Author(s)
      Yuma Fukutomi, Takafumi Minami, Jonas Lidholm, Akemi Saito, Kiyoshi Sekiya, Takahiro Tsuburai, Masami Taniguchi
    • Organizer
      European Academy of Allergy and Clinical Immunology Congress 2016
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-06-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 成人食物アレルギー Q and A2019

    • Author(s)
      福冨友馬
    • Total Pages
      142
    • Publisher
      日本医事新報社
    • ISBN
      9784784957132
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi