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Mechanism of neonatal thrombocytopenia focusing on thrombopoietin and its novel treatment

Research Project

Project/Area Number 16K19697
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionAichi Medical University

Principal Investigator

Takeshita Satoru  愛知医科大学, 医学部, 助教 (20715875)

Research Collaborator Aoyama Mineyoshi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords新生児 / 血小板 / トロンボポエチン / トロンボポエチン受容体 / 新生児血小板減少症 / 子宮内発育遅滞 / c-Mpl / エルトロンボパグ
Outline of Final Research Achievements

The cause of early birth thrombocytopenia in Small-for-Gestetional Age (SGA) infant was unknown. In this study, we focused on thrombopoietin, which is involved in thrombopoiesis, and divided it into preterm infants and full term infants, SGA children and non-SGA children and clarified the pathological condition. There was no rise in thrombopoietin in SGA children, suggesting thrombopoietin involving to thrombocytopenia in infants. Next, in order to conduct experiments using model rats of SGA children, model rats were created. The research results were presented at the academic meetings of relevant academic societies.

Academic Significance and Societal Importance of the Research Achievements

早期新生児における血小板減少症の原因は、多くが不明であり血小板輸血など対症療法にとどまっている。原因を明らかにすることで輸血に依存しない新たな治療薬の開発につながる。輸血の代替治療の研究は、医療社会資源の限られた現代において有益であると考えている。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Case report of Pierre Robin sequence with severe upper airway obstruction who was rescued by fiberoptic nasotracheal intubation.2017

    • Author(s)
      Satoru Takeshita, Hiroko Ueda, Tatenobu Goto, Hiroki Kakita, Kazuo Oshima, Takahisa Tainaka, Takayuki Ono, Yoshiaki Kazaoka, Yasumasa Yamada
    • Journal Title

      BMC anesthesiology

      Volume: 17 Issue: 1 Pages: 43-43

    • DOI

      10.1186/s12871-017-0336-0

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 早産児における血小板減少症の機序に関する考察2018

    • Author(s)
      竹下 覚
    • Organizer
      日本周産期新生児医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 早産児における血小板減少症の機序に関する考察2018

    • Author(s)
      竹下 覚、市村信太郎、上田博子、垣田博樹、山田恭聖
    • Organizer
      第54回周産期・新生児医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 早産児における高流量鼻カニューレの離脱時期に関する検討2017

    • Author(s)
      竹下 覚、上田博子、後藤盾信、武藤大輔、垣田博樹、山田恭聖
    • Organizer
      第53回周産期新生児医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 正常新生児における経皮的動脈血酸素飽和度のトレンド評価2017

    • Author(s)
      竹下 覚、上田博子、垣田博樹、山田恭聖
    • Organizer
      第62回日本新生児成育医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 早期新生児の血小板産生能に関する考察2016

    • Author(s)
      竹下 覚, 上田 博子, 後藤 盾信, 武藤 大輔, 垣田 博樹, 山田 恭聖
    • Organizer
      第61回日本新生児成育医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
  • [Book] 周産期医学 増大号「周産期のウイルス感染症」2017

    • Author(s)
      竹下 覚
    • Total Pages
      4
    • Publisher
      東京医学社
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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