Project/Area Number |
16K19699
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Embryonic/Neonatal medicine
|
Research Institution | Kansai Medical University |
Principal Investigator |
|
Project Period (FY) |
2016-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 高血圧 / エピジェネティクス / 子宮内胎児発育遅延 / hyperfiltration / 慢性腎臓病 / 慢性腎疾患 / エピジェティクス / 新生児医学 |
Outline of Final Research Achievements |
On day 21, both male and female rats had significantly lower body weights in the experimental group than the control group, and male rats on Day 200 had significantly higher systolic blood pressure than the control group. Regarding renal tissue, it was confirmed that the experimental group in male rats on day 200 tended to have a smaller number of glomeruli and a larger glomerular area than the control group. Therefore, it was considered that the increase in intraglomerular pressure due to hyperfiltration to the residual glomerulus is the cause of hypertension.
|
Academic Significance and Societal Importance of the Research Achievements |
胎児期のカルシウム(Ca)不足は胎児のエピジェネティクスに影響し、仔の低体重と、仔の成獣期における高血圧の発症率を高めるという事が明らかになった。高血圧は慢性腎臓病(CKD)の増悪因子である。 胎児期における母体の低Ca状態を予防すれば、CKDの進行により年々増加する新規透析導入患者数(現在の総透析患者数:約33万人)や心血管疾患患者数の減少に大きく貢献できる可能性が示唆された。
|