| Project/Area Number |
16K19705
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Hosokawa Rei 筑波大学, 医学医療系, 講師 (60463866)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 皮膚T細胞 / resident memory T細胞 / 皮膚免疫 / 皮膚resident memory T細胞 / 皮膚疾患 / central memory T細胞 / T細胞 |
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| Outline of Final Research Achievements |
The investigator isolated skin T cells from psoriasis, fixed drug eruption, discoid lupus erythematosus, systemic sclerosis patients and normal control, and compared the phenotype of skin T cells by flow cytometry anaysis. In psoriasis, CD103 positive CD8 resident memory T cells were found enriched both in lesion and nonlesion. These T cells, even in nonlesional sites, turned out to already possess a potential of IL-17A and are consideared to construct a "ready to go" condition in nonlesional skin. In disoid lupus erythematosus and dixed drug eruption, the investigator assumed the strong relation of resident memory T cells. However, the isolated T cells turned out to possess central memory phenotype. This result supports the idea that central memory T cells can also survey the peripheral tissues and can be converted to resident memory T cells once they enter into peripheral tissues. The investigator will track the change of the same clones to determine the change of T ell phenotype.
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