| Project/Area Number |
16K19720
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 末梢神経 / 好塩基球 / 皮膚 / 掻痒 / 皮膚免疫 / 好酸球 |
|---|
| Outline of Final Research Achievements |
Many patients with allergic skin diseases, such as atopic dermatitis (AD), have itching, but the details of the mechanism have still unknown. Recent studies have revealed that microbial dysbiosis, Staphylococcus aureus (S. aureus) colonization in particular, is correlated with disease severity in AD. Therefore, to evaluate the role of S. aureus in skin inflammation, we applied heat-killed S. aureus to the mice ears, and examined the role of skin peripheral nerves and immune cells. In it, it was proven that skin peripheral nerves and basophils cooperated and contributed to the formation of S. aureus-induced dermatitis.
|
| Academic Significance and Societal Importance of the Research Achievements |
アトピー性皮膚炎をはじめとるする多くの皮膚疾患は難治のかゆみを有するが、かゆみを制御する有効な治療法は未だ確立されているとは言えない。黄色ブドウ球菌誘発マウスモデルを利用し、末梢神経や免疫細胞の役割を解明することで、かゆみ制御につながる基盤研究となりうる。
|
