Epithelial mesenchymal transition in wound edge keratinocytes
| Project/Area Number |
16K19727
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Nagasaki University |
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Principal Investigator |
KOIKE Yuta 長崎大学, 医歯薬学総合研究科(医学系), 助教 (10530412)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 皮膚再生学 / 上皮間葉移行 / ＥＭＴ / ＦＧＦ2 / ｂＦＧＦ / EMT / bFGF |
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| Outline of Final Research Achievements |
During reepithelialization of the wound healing process, keratinocytes at leading edge of the wound edge are migrating in association with a transition into spindle cells and a reduction of cell-cell contact. These phenomena are thought to belong to epithelial mesenchymal transition (EMT). We examined bFGF effects on EMT at wound edge keratinocytes using mouse dorsal skin. As a result, EMT of keratinocytes at leading edge are enhanced with bFGF treatment and EMT inducer cytokines and transcriptional factors were also upregulated with bFGF.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Analysis of clinical symptoms and ABCC6 mutations in 76 Japanese patients with pseudoxanthoma elasticum.2017
Author(s)
Iwanaga A, Okubo Y, Yozaki M, Koike Y, Kuwatsuka Y, Tomimura S, Yamamoto Y, Tamura H, Ikeda S, Maemura K, Tsuiki E, Kitaoka T, Endo Y, Mishima H, Yoshiura KI, Ogi T, Tanizaki H, Wataya-Kaneda M, Hattori T, Utani A.
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Journal Title
Journal of Dermatology
Volume: 印刷中
Issue: 6
Pages: 644-650
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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