The role of lncRNA in pathogenesis of dermatomyositis

• Project/Area Number: 16K19729
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Kumamoto University
• Principal Investigator: AKI Ogata 熊本大学, 医学部附属病院, 非常勤診療医師 (80433035)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 皮膚筋炎 / long non cording RNA / Dermatomyositis / long-non coding RNA / dermatomyositis / 皮膚科学 / 膠原病

Outline of Final Research Achievements

Polymyositis and dermatomyositis are inflammatory muscular diseases of unknown origin, muscle, lung, and skin become the mainstay of lesions and rapid progressive interstitial pneumonia affects the prognosis of life. The skin symptoms seen in dermatomyositis are diverse, difficult to diagnose, occasionally refractory, and often do not respond to conventional treatment. The detailed mechanism of eruption is unknown and its elucidation may lead to early diagnosis and new treatment. We confirmed that lncRNA (dio3os, NTT) is elevated in the sera and tissues of DM patients and tried to elucidate the role of lncRNA in dermatomyositis.

Research Products

• [Journal Article] Bromoderma in a pituitary adenoma patient treated with bromocriptine. (2017)
  • Author(s): Maeda S, Kajihara I, Ogata A, Johno T, Jinnin M, Ihn H.
  • Journal Title: J Dermatol. Volume: 44 Issue: 5 Pages: 95-96
  • DOI: 10.1111/1346-8138.13683
  • Peer Reviewed
• [Journal Article] Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis. (2016)
  • Author(s): Tanigawa H, Miyata K, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Morinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Taketomi Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 34690-34690
  • DOI: 10.1038/srep34690
  • NAID: 120006534970
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Altered expression of CD63 and exosomes in scleroderma dermal fibroblasts. (2016)
  • Author(s): Nakamura K, Jinnin M, Harada M, Kudo H, Nakayama W, Inoue K, Ogata A, Kajihara I, Fukushima S, Ihn H.
  • Journal Title: J Dermatol Sci. Volume: 1 Issue: 1 Pages: 30-39
  • DOI: 10.1016/j.jdermsci.2016.06.013
  • Peer Reviewed / Open Access
• [Presentation] 熊本地震における当院の対応 (2017)
  • Author(s): 緒方亜紀
  • Organizer: 第33回日本臨床皮膚科医 九州ブロック総会
• [Presentation] 熊本地震における当院の対応 (2017)
  • Author(s): 緒方亜紀
  • Organizer: 第145回熊本皮膚科医会例会
• [Presentation] 臀部に生じた毛包棘細胞腫(Pilar sheath Acanthoma)の1例 (2016)
  • Author(s): 緒方 亜紀
  • Organizer: 第219回 日本皮膚科学会熊本地方会
  • Place of Presentation: 熊本大学医学教育図書棟３階 第一講義室
  • Year and Date: 2016-12-04