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Investigating a subtype of schizophrenia using carbonyl stress and abnormal connectivity

Research Project

Project/Area Number 16K19763
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionKyoto University

Principal Investigator

Son Shuraku  京都大学, 医学研究科, 研究員 (60771524)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsカルボニルストレス / 統合失調症 / MRI
Outline of Final Research Achievements

A total of 53 patients with schizophrenia and 83 age- and gender-matched healthy controls were recruited. We used plasma pentosidine, an AGE, and serum pyridoxal as carbonyl stress markers. Between-group differences in these carbonyl stress markers and their relationships with white matter integrity were investigated using Tract-Based Spatial Statistics. In the schizophrenia group, plasma pentosidine level was significantly higher and serum pyridoxal level was lower than those of controls. There was a significant negative correlation between plasma pentosidine and white matter integrity in the schizophrenia group, but not in the control group. Our findings suggest that enhanced carbonyl stress is a possible underlying mechanism of white matter microstructural disruption in schizophrenia.

Academic Significance and Societal Importance of the Research Achievements

今回我々は統合失調症におけるカルボニルストレスの亢進が大脳白質構造の異常と関連することを初めて報告した。本研究でその神経学的根拠を示すことにより、統合失調症診断群における脳構造変化に関わる新たな交絡因子の提案、治療抵抗性統合失調症及び精神病発症危険状態へのビタミンB6補充による新規治療・介入法の開発など、統合失調症研究・臨床治療現場に対する学術的意義、社会的意義は大きいと予想される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Gray matter volume reductions in patients with schizophrenia: A replication study across two cultural backgrounds2019

    • Author(s)
      Koelkebeck Katja、Dannlowski Udo、Ohrmann Patricia、Suslow Thomas、Murai Toshiya、Bauer Jochen、Pedersen Anya、Matsukawa Noriko、Son Shuraku、Haidl Theresa、Miyata Jun
    • Journal Title

      Psychiatry Research: Neuroimaging

      Volume: 292 Pages: 32-40

    • DOI

      10.1016/j.pscychresns.2019.08.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of phase-encoding direction on group analysis of resting-state functional magnetic resonance imaging2018

    • Author(s)
      Mori Yasuo、Miyata Jun、Isobe Masanori、Son Shuraku、Yoshihara Yujiro、Aso Toshihiko、Kouchiyama Takanori、Murai Toshiya、Takahashi Hidehiko
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 72 Issue: 9 Pages: 683-691

    • DOI

      10.1111/pcn.12677

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.2018

    • Author(s)
      Kushima I, (27名中略), Hashimoto R,(80名中29番目) , et al.
    • Journal Title

      Cell Rep

      Volume: 24(11) Issue: 11 Pages: 2838-2856

    • DOI

      10.1016/j.celrep.2018.08.022

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia: Analysis of 778 subjects2018

    • Author(s)
      Hashimoto Naoki、Ito Yoichi M.、Okada Naohiro、Yamamori Hidenaga、Yasuda Yuka、Fujimoto Michiko、et al.
    • Journal Title

      Neuroimage Clin

      Volume: 17 Pages: 563-569

    • DOI

      10.1016/j.nicl.2017.11.004

    • NAID

      120006463564

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lateralization of intrinsic frontoparietal network connectivity and symptoms in schizophrenia.2017

    • Author(s)
      on S, Miyata J, Mori Y, Isobe M, Urayama SI, Aso T, Fukuyama H, Murai T, Takahashi H.
    • Journal Title

      Psychiatry Res.

      Volume: 260 Pages: 23-28

    • DOI

      10.1016/j.pscychresns.2016.12.007

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distinct Patterns of Cerebral Cortical Thinning in Schizophrenia: A Neuroimaging Data-Driven Approach.2016

    • Author(s)
      Sugihara G, Oishi N, Son S, Kubota M, Takahashi H, Murai T.
    • Journal Title

      Schizophr Bull.

      Volume: - Pages: 900-906

    • DOI

      10.1093/schbul/sbw176

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Creativity and Positive Symptoms Revisited:Structural Connectivity Analysis with Diffusion Tensor Imaging2019

    • Author(s)
      Shuraku Son
    • Organizer
      WFSBP2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between Creativity and Positive Symptoms Revealed by Structural Connectivity Analysis2019

    • Author(s)
      Shuraku Son
    • Organizer
      第41回日本生物学的精神医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 統合失調症におけるカルボニルストレスと白質統合性について2018

    • Author(s)
      孫 樹洛
    • Organizer
      第40回日本生物学的精神医学会、第61回日本神経科学会大会 合同年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Shuraku Son, Makoto Arai, Kazuya Toriumi, Hiroto Mizuta, Jun Miyata, Takuya Hayashi, Shin-ichi Urayama, Toshihiko Aso, Hidenao Fukuyama, Masanari Itokawa, Toshiya Murai2017

    • Author(s)
      Relationships between enhanced carbonyl stress and white matter integrity in schizophrenia using diffusion tensor imaging
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Enhanced carbonyl stress and white matter disruption in schizophrenia: diffusion tensor imaging study2017

    • Author(s)
      Shuraku Son, Makoto Arai, Kazuya Toriumi, Hiroto Mizuta, Jun Miyata, Takuya Hayashi, Shin-ichi Urayama, Toshihiko Aso, Hidenao Fukuyama, Masanari Itokawa, Toshiya Murai
    • Organizer
      WPA XVII WORLD CONGRESS OF PSYCHIATRY
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 統合失調症におけるカルボニルストレスと白質統合性について2017

    • Author(s)
      孫 樹洛
    • Organizer
      第17回精神疾患と認知機能研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Enhanced carbonyl stress and white matter disruption in schizophrenia2016

    • Author(s)
      Shuraku Son, Makoto Arai, Kazuya Toriumi, Shin-ichi Urayama, Toshihiko Aso, Hidenao Fukuyama, Masanari Itokawa, Toshiya Murai
    • Organizer
      Organization for Human Brain Mapping 2016
    • Place of Presentation
      Palexpo Exhibition and Congress Centre Geneva, Switzerland
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 精神科研修ノート第2版2016

    • Author(s)
      孫樹洛
    • Total Pages
      640
    • Publisher
      診断と治療社
    • Related Report
      2016 Research-status Report
  • [Book] 精神科治療学 第31巻増刊号 統合失調症のベストプラクティス2016

    • Author(s)
      孫樹洛, 宮田淳, 村井俊哉
    • Total Pages
      436
    • Publisher
      星和書店
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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