Comprehensive analysis of the synaptotagmin gene family in drug-induced parkinsonisms.
| Project/Area Number |
16K19775
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 統合失調症 / 薬剤性パーキンソニズム / シナプトタグミン / 抗精神病薬 / 遺伝子解析 |
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| Outline of Final Research Achievements |
We performed a comprehensive mutation analysis of the synaptotagmin gene family in schizophrenic patients with drug-induced parkinsonisms. We found a novel heterozygous mutation, c.-18+47G/A, in intron 4 of the Synaptotagmin 1 gene in a patient with drug-induced dystonia.
In addition, we found different patterns of drug-induced parkinsonisms in 22q11.2 deletion syndrome patients with schizophrenia-like psychosis.
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Report
(3 results)
Research Products
(10 results)
