Developing a new MRI/CT image-guided brachytherapy for cervical cancer by 3D MRI imaging

• Project/Area Number: 16K19808
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Chiba University
• Principal Investigator: Watanabe Miho 千葉大学, 大学院医学研究院, 講師 (50568665)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 子宮頸癌 / MRI based IGBT / 画像誘導小線源治療 / IGBT / MRI / 放射線治療

Outline of Final Research Achievements

3D Image-Guided Brachytherapy (3D IGBT) has been developed for the treatment planning of cervical cancer by obtaining 3D images such as MRI and CT with the applicator inserted during intracavitary irradiation. Based on the current situation in Japan where MRI imaging for each intracavitary irradiation is difficult, we established and clinically applied MRI/CT image based IGBT, which is based on MRI and CT imaging for the first time and CT only for the second time and thereafter.

Academic Significance and Societal Importance of the Research Achievements

アクセスの限られるMRを最大限に活用し、汎用性があり患者スループットの向上が見込めるCTと組み合わせることで、高精度なIGBTの普及が期待できる点が、本研究の学術的、社会的意義である。また、子宮頸癌は開発途上国で罹患数が多い疾患であり、本研究の意義は日本のみならず開発途上国へも波及するものと考えられる。

Research Products

• [Journal Article] Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma (2017)
  • Author(s): Nemoto Miho Watanabe、Iwai Yuma、Togasaki Gentaro、Kurokawa Marie、Harada Rintarou、Kobayashi Hiroki、Uno Takashi
  • Journal Title: Japanese Journal of Radiology Volume: 35 Issue: 12 Pages: 760-765
  • DOI: 10.1007/s11604-017-0690-3
  • Peer Reviewed / Open Access
• [Presentation] 子宮頸癌に対する画像誘導小線源治療併用の放射線治療成績 (2019)
  • Author(s): 渡辺未歩 岩井祐磨 黒川茉梨絵 齋藤真 原田倫太郎 小林裕樹 宇野隆
  • Organizer: 日本放射線腫瘍学会第32回学術大会
• [Presentation] Single-Institution Experience in 3D MRI/CT-Based Brachytherapy for Cervical Cancer. (2019)
  • Author(s): Watanabe-Nemoto, Miho Iwai, Yuma Kanazawa, Aki Kurokawa, Marie Harada, Rintarou Kobayashi, Hiroki Uno, Takashi
  • Organizer: American Society for Radiation Oncology
  • Int'l Joint Research
• [Presentation] Long-term results of radiotherapy in 2D-ICRT era for cervical cancer patients (2018)
  • Author(s): Miho Watanabe
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] Long-term results of radiotherapy in 2D-ICRT era for cervical cancer patients (2018)
  • Author(s): Miho Watanabe
  • Organizer: 17th Biennial Meeting of the International Gynecologic Cancer Society
  • Int'l Joint Research
• [Presentation] 子宮頸癌に対するMRI/CT based Hybrid brachytherapy(HBT)の 初期経験 (2018)
  • Author(s): 渡辺未歩
  • Organizer: 小線源治療部会第20回学術大会
• [Presentation] The effect of intravenous sedation for late rectal hemorrhage in intracavitary radiotherapy for cervical cancer (2017)
  • Author(s): Watanabe-Nemoto, Miho Togasaki, Gentaro Iwai, Yuma Kurokawa, Marie Harada, Rintarou Kobayashi, Hiroki Usui, Hirokazu Mitsuhashi, Akira Shozu, Makio
  • Organizer: The 5th Biennial Meeting of Asian Society of Gynecologic Oncology
  • Int'l Joint Research
• [Presentation] 子宮頸癌に対する MRI/CT based Image guided brachytherapyの初期経験 (2017)
  • Author(s): 渡辺未歩 岩井祐磨 東ヶ崎厳太郎 黒川茉梨絵 原田倫太郎 小林裕樹 宇野隆
  • Organizer: 第59回日本婦人科腫瘍学会学術講演会
• [Presentation] 子宮頸癌に対する MRI/CT based Image guided brachytherapyの初期経験 (2017)
  • Author(s): 渡辺未歩 岩井祐磨 東ヶ崎厳太郎 黒川茉梨絵 原田倫太郎 小林裕樹 宇野隆
  • Organizer: 日本放射線腫瘍学会小線源治療部会第19回学術大会
• [Presentation] 子宮頸癌に対する MRI/CT based Image guided brachytherapyの初期経験 (2017)
  • Author(s): 渡辺未歩 岩井祐磨 東ヶ崎厳太郎 黒川茉梨絵 原田倫太郎 小林裕樹 宇野隆
  • Organizer: 日本放射線腫瘍学会第30回学術大会
• [Presentation] Multi-institutional study of MR imaging technique in cervical cancer image guided brachytherapy (2016)
  • Author(s): Nemoto MW, Ikeda Y, Ii N, Toita T, Togasaki G, Kanazawa A, et al.
  • Organizer: The 29th Annual Meeting of the Japanese Society for Radiation Oncology
  • Place of Presentation: 京都国際会館（京都府、京都市）
  • Year and Date: 2016-11-25
• [Presentation] Multi-Institutional Comparative Study of MRI Technique in Cervical Cancer Image-Based Brachytherapy (IGBT): 3D MRI With High Sampling Efficiency Versus Conventional 2D Multiplanar MRI. (2016)
  • Author(s): Nemoto MW, Ikeda Y, Ii N, Toita T, Togasaki G, Kanazawa A, et al.
  • Organizer: Annual Meeting- American Society for Radiation Oncology
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Preliminary Results of MRI/CT Based Image Guided Brachytherapy in Cervical Carcinoma (2016)
  • Author(s): Watanabe M, Iwai Y, Togasaki G, Kanazawa A, Kurokawa M, Harada R, et al.
  • Organizer: 2016 World Congress of Brachytherapy
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2016-06-27
  • Int'l Joint Research
• [Presentation] 子宮頚癌MRI based IGBTにおける3D MRI撮像方法 (2016)
  • Author(s): Watanabe M, Ii N, Toita T, Togasaki G, Kanazawa A, Kurokawa M, et al.
  • Organizer: 小線源治療部会第18回学術大会
  • Place of Presentation: ホテルエルセラーン大阪（大阪府、大阪市）
  • Year and Date: 2016-05-27