Evaluation of QPR using Dynamic CT Perfusion

• Project/Area Number: 16K19826
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Ehime University
• Principal Investigator: Kido Teruhito 愛媛大学, 医学系研究科, 講師 (50403837)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: Cardiac CT / CT Perfusion / FFR / coronary CTA / Territory Map / Dynamic CT perfusion / Myocardial Blood Flow / QPR / 定量解析 / Perfusion CT / 虚血性心疾患 / 心筋シンチ / 心臓MRI / 放射線 / X線 / 循環器・高血圧

Outline of Final Research Achievements

In recent years, coronary artery disease in Japan has been increasing, accurate diagnosis and evaluation of therapeutic indication are required. However, it is known that sufficient improvement of patient prognosis can not be obtained by evaluation of therapeutic indication by morphological evaluation such as conventional coronary stenosis ratio. Therefore, the non-invasive and objective method of evaluating ischemia was expected. In this study,we proposed Quantitative Perfusion Ratio (QPR) calculated from the Dynamic CT Perfusion and examined its accuracy.

Research Products

• [Journal Article] Peak enhancement ratio of myocardium to aorta for identification of myocardial ischemia using dynamic myocardial computed tomography perfusion imaging (2017)
  • Author(s): Tanabe Yuki、Kido Teruhito、Kurata Akira、Yokoi Takahiro、Fukuyama Naoki、Uetani Teruyoshi、Nishiyama Hikaru、Kawaguchi Naoto、Tahir Enver、Miyagawa Masao、Mochizuki Teruhito
  • Journal Title: Journal of Cardiology Volume: 70 Issue: 6 Pages: 565-570
  • DOI: 10.1016/j.jjcc.2017.04.002
  • Peer Reviewed
• [Journal Article] Myocardial Segmentation of Area at Risk Based on Coronary Computed Tomography Angiography and Voronoi Diagram in Comparison with Magnetic Resonance Perfusion Imaging (2017)
  • Author(s): Fukuyama Naoki、Kido Teruhito、Kurata Akira、Tanabe Yuki、Kido Tomoyuki、Yokoi Takahiro、Ogawa Ryo、Nishiyama Hikaru、Uetani Teruyoshi、Mochizuki Teruhito
  • Journal Title: Open Journal of Radiology Volume: 07 Issue: 01 Pages: 9-22
  • DOI: 10.4236/ojrad.2017.71002
  • Peer Reviewed / Open Access
• [Journal Article] Optimal Scan Time for Single-Phase Myocardial Computed Tomography Perfusion to Detect Myocardial Ischemia – Derivation Cohort From Dynamic Myocardial Computed Tomography Perfusion – (2016)
  • Author(s): Tanabe Yuki, Kido Teruhito, et al.
  • Journal Title: Circulation Journal Volume: 80 Issue: 12 Pages: 2506-2512
  • DOI: 10.1253/circj.CJ-16-0834
  • NAID: 130005284986
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Comparison of QPR derived from Dynamic CT Perfusion and FFR on the evaluation of myocardial ischemia. (2018)
  • Author(s): Natsumi Kuwahara, Teruhito Kido, Takahiro Yokoi, Yuki Tanabe, Hikaru Nishiyama, Teruyoshi Uetani*, Kuniaki Hirai, Naoto Kawaguchi, Akira Kurata, Masao Miyagawa, Teruhito Mochizuki
  • Organizer: 第77回日本医学放射線学会総会
• [Presentation] Diagnostic Performance of Peak Enhancement Ratio of Myocardium to Aorta for Detecting Myocardial Ischemia in Dynamic Myocardial Computed Tomography Perfusion Imaging RSNA 102th Scientific Assembly and Annual Meeting. (2016)
  • Author(s): Yuki Tanabe
  • Organizer: RSNA
  • Place of Presentation: Chicago
  • Year and Date: 2016-12-01
  • Int'l Joint Research
• [Presentation] Myocardial Blood Flow with Myocardial Segmentation of the Area at Risk Based on Stress Dynamic Perfusion Computed Tomography: Validation by Using Fractional Flow Reserve. (2016)
  • Author(s): Fukuyama Naoki
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-04-11