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Multiparametric voxel-based analysis of soft-tissue tumors with a PET/MR system

Research Project

Project/Area Number 16K19827
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

Sagiyama Koji  九州大学, 大学病院, 助教 (20755243)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsPET/MR / 骨軟部腫瘍 / FDG-PET / 拡散強調像 / Voxel-based analysis / APT imaging / Amide proton transfer / 放射線医学 / 治療効果判定
Outline of Final Research Achievements

A hybrid PET/MR system has recently been developed that enables the acquisition of FDG-PET and MRI simultaneously, and precise image co-registration. We showed that the comprehensive assessment of soft-tissue tumors via multiparametric voxel-based analysis could facilitate the diagnosis of malignancy of soft-tissue tumors

Academic Significance and Societal Importance of the Research Achievements

本研究は複数の機能画像を同時に高精細に取得できるPET/MR装置ならではの手法である。また、本研究の手法は発展性が高く、脳腫瘍や頭頚部腫瘍といった他部位の腫瘍への応用、良悪性診断のみならず治療効果の判定や予測などにも応用が可能である。また用いる機能画像に関してもPETおよびMRIの両者で様々に拡張性があり、PET/MR装置のマルチ分子イメージング装置としての可能性を切り拓く研究であると言える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results) Presentation (9 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Multiparametric voxel-based analyses of standardized uptake values and apparent diffusion coefficients of soft-tissue tumours with a positron emission tomography/magnetic resonance system: Preliminary results2017

    • Author(s)
      Sagiyama Koji、Watanabe Yuji、Kamei Ryotaro、Hong Sungtak、Kawanami Satoshi、Matsumoto Yoshihiro、Honda Hiroshi
    • Journal Title

      European Radiology

      Volume: 27 Issue: 12 Pages: 5024-5033

    • DOI

      10.1007/s00330-017-4912-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of positron emission tomography diffusion-weighted imaging (PET/DWI) registration quality in a PET/MR scanner: Zoomed DWI vs. Conventional DWI2016

    • Author(s)
      Sagiyama K, Watanabe Y, Kamei R, Baba S, Honda H
    • Journal Title

      J. Magn. Reson. Imaging

      Volume: 43 Issue: 4 Pages: 853-858

    • DOI

      10.1002/jmri.25059

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An improved MR sequence for attenuation correction in PET/MR hybrid imaging2016

    • Author(s)
      Sagiyama K, Watanabe Y, Kamei R, Shinyama D, Baba S, Honda H
    • Journal Title

      Magn. Reson. Imaging

      Volume: 34 Issue: 3 Pages: 345-352

    • DOI

      10.1016/j.mri.2015.10.037

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Voxel-wise ratios of amide proton transfer (APT) signals and standardized uptake values (SUVs) of fluorodeoxyglucose (FDG) in the differentiation of myxoid-rich soft-tissue tumors with FDG-PET/MR imaging2018

    • Author(s)
      Sagiyama K, Watanabe Y, Ishimatsu K, Kamitani T, Yamasaki Y, Matsuura Y, Hino T, Tsutsui S, Yabuuchi H, Hong S, Keupp J, Matsumoto Y, Honda H
    • Organizer
      26th Annual Meeting International Society for Magnetic Resonance in Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Voxel-wise ratios of amide proton transfer signals and SUVs of FDG-PET in differentiating liposarcomas from myxofibrosarcomas with a PET/MR system2018

    • Author(s)
      Sagiyama K, Ishimatsu K, Nakayama T, Hiwatashi A, Kamitani T, Yamasaki Y, Matsuura Y, Hino T, Tsutsui S, Yabuuchi H, Keupp J, Matsumoto Y, Honda H
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Comparison of Amide Proton Transfer (APT) Imaging with FDG-PET on a PET/MR System2017

    • Author(s)
      Sagiyama K, Watanabe Y, Kamei R, Hong S, Kawanami S, Honda H
    • Organizer
      第76回日本医学放射線学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Voxel-based comparison of amide proton transfer (APT) weighted image and fluorodeoxyglucose (FDG)-PET in soft-tissue tumors with a PET/MR system2017

    • Author(s)
      Sagiyama K, Watanabe Y, Kamei R, Hong S, Kawanami S, Matsumoto Y, Honda H
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Voxel-wise comparison of amide proton transfer (APT) weighted image and fluorodeoxyglucose (FDG)-PET in brain tumors with a PET/MR system2017

    • Author(s)
      Sagiyama K, Watanabe Y, Kamei R, Hong S, Keupp J, Honda H
    • Organizer
      25th Annual Meeting International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Voxel-based analysis of SUVs and ADCs in a PET/MR system: Initial experience in the evaluation of treatment effect of soft-tissue tumors.2016

    • Author(s)
      Sagiyama K, Watanabe Y, Kamei R, Hong S, Kawanami S, Matsumoto Y, Honda H
    • Organizer
      102nd Scientific Assembly and Annual Meeting of Radiological Society of North America
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of treatment effect in soft-tissue sarcoma with multiparametric voxel-based analysis of SUVs and ADCs in a PET/MR system2016

    • Author(s)
      Sagiyama K, Watanabe Y, Kamei R, Hong S, Kawanami S, Matsumoto Y, Honda H
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      さいたま市
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Multiparametric voxel-based analysis of standardized uptake values and apparent diffusion coefficients in soft-tissue tumors with a positron emission tomography-magnetic resonance system: Application for evaluation of treatment effect2016

    • Author(s)
      Sagiyama K, Watanabe Y, Kamei R, Hong S, Kawanami S, Matsumoto Y, Honda H
    • Organizer
      24th Annual Meeting International Society for Magnetic Resonance in Medicine May 7-13, 2016 Singapore
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multiparametric Voxel-based Analyses of SUVs and ADCs of Soft-tissue Tumors with a PET/MR System2016

    • Author(s)
      Sagiyama K, Watanabe Y, Kamei R, Hong S, Kawanami S, Matsumoto Y, Honda H
    • Organizer
      第75回日本医学放射線学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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