| Project/Area Number |
16K19840
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Goto Mariko 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20605042)
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| Research Collaborator |
Kiba Maki
Yoshida Mariko
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 乳癌 / 乳房MRI / ガドリニウム造影剤 / 早期造影動態解析 / 乳房ダイナミックMRI / Breast cancer / dynamic MRI |
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| Outline of Final Research Achievements |
In this research, we assessed the diagnostic value and contribution to BI-RADS categorisation of initial enhancement on ultra-fast dynamic contrast enhanced MRI
for differentiating malignant and benign breast lesions. As a result, initial enhancement analysis using ultra-fast MRI is especially useful for increasing the diagnostic performance of non-mass enhancement in breast MRI. In addition, the invasive breast carcinoma with poor histological prognostic factors (e.g. high histologic grade, hormone receptor negativity, and Ki67 positivity) showed significantly earlier and stronger enhancement in the ultra-fast MRI than the ones with good prognostic factors.
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| Academic Significance and Societal Importance of the Research Achievements |
乳房MRIによる乳腺病変良悪性診断は、高い感度を有するが、特異度が低くばらつきがあるのがこれまでの問題であった。本研究から得られた早期造影動態解析には特異度を改善する効果があることが示され、結果としてMRIによる乳腺病変診断能改善効果が得られることが分かった。特異度の改善により、乳腺病変に対する不必要な生検を避けられる可能性があり臨床的に意義のある結果といえる。
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