Basic research for standardization of IR procedure relating to Beads-TACE for liver cancer

Research Project

Project/Area Number	16K19843
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Nara Medical University
Principal Investigator	Sato Takeshi 奈良県立医科大学, 医学部附属病院, 研究員 (80773788)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords	薬剤溶出性ビーズ / DEB-TACE / ビーズサイズ / VX2腫瘍 / 非多血性肝腫瘍 / ビーズTACE / 血管モデル / 光ファイバーセンサー / ビーズカウンター / ビーズ / TACE / ドラッグデリバリーシステム / ウサギ肝腫瘍モデル
Outline of Final Research Achievements	In our in vivo study, pharmacokinetics and histopathological findings of transarterial chemoembolization (TACE) using drug-eluting beads (DEB-TACE) were evaluated in a rabbit VX2 liver tumor model. As a result of our in vivo study, small size microspheres can contribute to the better distribution of microspheres and a higher drug concentration in non-hypervascular liver tumors such as VX2 tumor.