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Drug repositioning for mitigation of radiation-induced lung injury

Research Project

Project/Area Number 16K19866
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionOsaka Medical College

Principal Investigator

Yoshikawa Nobuhiko  大阪医科大学, 医学部, 非常勤講師 (10719917)

Research Collaborator Okada Yoshikatsu  
Nonoguchi Naosuke  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords放射線治療 / 放射線肺障害 / 漢方薬 / 放射線肺臓炎 / 補中益気湯 / ドラッグリポジショニング / 放射線防護
Outline of Final Research Achievements

We had tried some drugs which may mitigate radiation-induced lung injury (RILI) in mice and determined a Japanese herbal medicine TJ-41 as a potential drug. The irradiated mice with TJ-41 were observed milder RILI than without TJ-41 but not statistically. We analyze the difference of gene expression level between the two groups, however, we couldn’t list up the gene which may contribute to mitigate RILI.
In secondary analysis, we found out two interesting facts. First, animal CT system were very useful for detecting mild RILI without sacrificing mice. So we can reduce the number of mouse in future study. Second, skin fibrosis in the group of irradiation + TJ-41 was milder than that of irradiation only by visual evaluation, and this may indicate TJ-41 has protective effects of other organs.

Academic Significance and Societal Importance of the Research Achievements

本研究の主目的を達成する既存薬は見い出せなかったが、肺以外の臓器保護効果についても示唆されたため、新たな研究につながる可能性のある結果となった。また動物用CTによる肺障害の経過観察が可能となり、今後実験に用いるマウス数を減らすことができ倫理面でも大きな貢献が期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2018 2016

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 動物実験用X線CT装置はマウスにおける軽度の晩期放射線肺障害の検出に有用である2018

    • Author(s)
      吉川信彦 吉田謙 新保大樹 吉岡裕人 中田美緒 堀章裕 鳴海善文
    • Organizer
      第54回日本医学放射線学会秋季臨床大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] General fatigue during the period of post-operative radiotherapy for breast cancer patients; Clinical usefulness of Japanese herbal medicine.2016

    • Author(s)
      吉川信彦、新保大樹、吉岡裕人、吉田謙、上杉康夫、鳴海善文
    • Organizer
      The European SocieTy for Radiotherapy & Oncology 35
    • Place of Presentation
      トリノ、イタリア
    • Year and Date
      2016-04-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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