Drug repositioning for mitigation of radiation-induced lung injury
| Project/Area Number |
16K19866
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Research Collaborator |
Okada Yoshikatsu
Nonoguchi Naosuke
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 放射線治療 / 放射線肺障害 / 漢方薬 / 放射線肺臓炎 / 補中益気湯 / ドラッグリポジショニング / 放射線防護 |
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| Outline of Final Research Achievements |
We had tried some drugs which may mitigate radiation-induced lung injury (RILI) in mice and determined a Japanese herbal medicine TJ-41 as a potential drug. The irradiated mice with TJ-41 were observed milder RILI than without TJ-41 but not statistically. We analyze the difference of gene expression level between the two groups, however, we couldn’t list up the gene which may contribute to mitigate RILI.
In secondary analysis, we found out two interesting facts. First, animal CT system were very useful for detecting mild RILI without sacrificing mice. So we can reduce the number of mouse in future study. Second, skin fibrosis in the group of irradiation + TJ-41 was milder than that of irradiation only by visual evaluation, and this may indicate TJ-41 has protective effects of other organs.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の主目的を達成する既存薬は見い出せなかったが、肺以外の臓器保護効果についても示唆されたため、新たな研究につながる可能性のある結果となった。また動物用CTによる肺障害の経過観察が可能となり、今後実験に用いるマウス数を減らすことができ倫理面でも大きな貢献が期待できる。
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Report
(4 results)
Research Products
(2 results)
