| Project/Area Number |
16K19898
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAKAO Toshihiro 徳島大学, 大学院医歯薬学研究部(医学系), 徳島大学特別研究員 (60531754)
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| Research Collaborator |
YOSHIKAWA Kozo 徳島大学, 病院, 講師 (80448331)
HIGASHIJIMA Jun 徳島大学, 病院, 助教 (30467815)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 胃癌 / 免役チェックポイント / THBS-1 / 発癌 / Thrombospondin 1 / CD47 / TSP-1 / SHP / STAT3 / PD-1 / PDL-1 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the impact of correlation between TSP-1 and immune-checkpoint and clarify the role of TSP1 in gastric carcinogenesis. TSP-1 and PD-1 was a significant prognostic factor. Furthermore TSP1 was correlated with TGFβ expression.The expression of TSP1 was high in the mucosal atrophy group and tended to be high in the Helicobacter pylori (H.pylori) (+) and multiple cancer groups. The levels of CD36, STAT3 and TGFβR2 mRNA were significantly higher in the TSP1 high group. TSP1 signaling pathway was induced in multiple cancer or atrophy (+) or H.pylori (+) compared tocases with single cancer, atrophy (-) and H.pylori (-). Expression of proteins involved in the TSP1 signaling pathway in non-cancer tissues with multiple gastric cancers were higher than that with single gastric cancer.
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